BACKGROUND Infertility affects∼ 7% of all men. Despite much progress, mainly in
genetics, its etiology remains obscure in∼ 50% of cases. To fill this gap, imaging of the male …

Autosomal dominant polycystic kidney disease is the most prevalent, potentially lethal,
monogenic disorder. It is associated with large interfamilial and intrafamilial variability, which …

When we edited in 2007 the first issue on transient receptor potential channel in the
Handbook of Experimental Pharmacology, we were all very excited by the progress in this …

The differential diagnosis between obstructive and nonobstructive azoospermia is the first
step in the clinical management of azoospermic patients with infertility. It includes a detailed …

Autosomal-dominant polycystic kidney disease (ADPKD) is a systemic disease, marked by
progressive increase of bilateral renal cysts, resulting in chronic kidney disease (CKD) and …

Autosomal dominant polycystic kidney disease (ADPKD) is generally a late-onset
multisystem disorder characterized by bilateral kidney cysts, liver cysts, and an increased …

Spermatogenesis is a cell differentiation process that ensures the production of fertilizing
sperm, which ultimately fuse with an egg to form a zygote. Normal spermatogenesis relies …

The seminal vesicle (SV) and vas deferens (VD) are ancillary but essential urogenital
organs. Understanding their embryologic features and anatomy can be helpful in evaluating …

Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations in PKD1 or
PKD2, which encode polycystin-1 and polycystin-2, respectively. Rodent models are …

Abstract Polycystin 2 (PC2) is one of two main protein types responsible for the underlying
etiology of autosomal dominant polycystic kidney disease (ADPKD), the most prevalent …