Connexins are ubiquitous channel forming proteins that assemble as plasma membrane
hemichannels and as intercellular gap junction channels that directly connect cells. In the …

Gap junctions (GJ), specialised membrane structures that mediate cell-to-cell
communication in almost all animal tissues, are composed of intercellular channel-forming …

Recombinant proteins containing tetracysteine tags can be successively labeled in living
cells with different colors of biarsenical fluorophores so that older and younger protein …

Intercellular co-operation is a fundamental and widespread feature in tissues and organs.
An important mechanism ensuring multicellular homoeostasis involves signalling between …

The assembly of gap junctions was investigated in mammalian cells expressing connexin
(Cx) 26, 32 and 43 fused to green, yellow or cyan fluorescent proteins (GFP, YFP, CFP) …

Gap junctional channels are a class of membrane channels composed of transmembrane
channel-forming integral membrane proteins termed connexins, innexins or pannexins that …

Gap junctions, specialised membrane structures that mediate cell-to-cell communication in
almost all tissues, are composed of channel-forming integral membrane proteins termed …

Gap junctions are polymeric assemblies of aligned pairs of interacting hexameric connexon
hemichannel units facilitating direct intercellular communication. The principal process …

Abstract Connexin 43 (Cx43), the most widely expressed gap junction protein, has a role in
regulation of cell growth. In this study, we demonstrate that the point mutations F199L …

1. PREFACE This thesis is based on the work carried in the Vascular Smooth Muscle group
at the Institute of Physiology and Biophysics, Aarhus University. This thesis is focused on a …