Pathophysiology of type 2 diabetes

J Kesavadev, F Jawad, A Deeb, A Coetzee… - The Diabetes Textbook …, 2023 - Springer
In former times, type 2 diabetes (T2D) was considered a disease associated with disruptions
in the functioning of the pancreas. Later on, a surfeit of evidence revealed a series of …

[HTML][HTML] Improved framingham risk scores of patients with Type 2 Diabetes Mellitus in the Beijing Community: A 10-Year prospective study of the effects of multifactorial …

XL Zhang, G Wan, MX Yuan, GR Yang, HJ Fu, LX Zhu… - Diabetes Therapy, 2020 - Springer
Introduction To date, research is lacking on the development of a cardiovascular disease
(CVD) risk assessment tool for people with diabetes mellitus, in general, and for Chinese …

Angiotensin converting enzyme inhibitors for prevention of new-onset type 2 diabetes mellitus: A meta-analysis of 72,128 patients

D Geng, D Jin, W Wu, J Wang - International journal of cardiology, 2013 - Elsevier
Backgroud Angiotensin converting enzyme inhibitors (ACEIs) have been linked to reduced
risk of new-onset diabetes, but the evidence was insufficient. Objective and methods The …

Telmisartan improves vascular function independently of metabolic and antihypertensive effects in hypertensive subjects with impaired glucose tolerance

S Perl, I Schmölzer, H Sourij, H Pressl, M Eder… - International journal of …, 2010 - Elsevier
BACKGROUND: Hypertensive patients with IGT have increased risk for cardiovascular
disease and progression to diabetes mellitus. Clinical trials suggest that the ARB telmisartan …

The role of renin–angiotensin system inhibition in the treatment of hypertension in metabolic syndrome: are all the angiotensin receptor blockers equal?

A Karagiannis, DP Mikhailidis, VG Athyros… - Expert opinion on …, 2007 - Taylor & Francis
The metabolic syndrome (MetS) is a strong predictor of cardiovascular morbidity and
mortality, as well as new Type 2 diabetes. MetS consists of visceral obesity, elevated blood …

Effects of telmisartan on insulin resistance in Japanese type 2 diabetic patients

M Watanabe, K Inukai, T Sumita, K Ikebukuro, D Ito… - Internal …, 2010 - jstage.jst.go.jp
Objective PPARγ agonists are widely used in type 2 diabetic patients to reduce insulin
resistance. Recently, telmisartan, an AT1 receptor antagonist, was reported to function as a …

Effect of angiotensin receptor blockade on insulin sensitivity and endothelial function in abdominally obese hypertensive patients with impaired fasting glucose

TS Perlstein, RR Henry, KJ Mather, MR Rickels… - Clinical …, 2012 - portlandpress.com
AngII (angiotensin II) may contribute to cardiovascular risk in obesity via adverse effects on
insulin sensitivity and endothelial function. In the present study, we examined the effects of …

Effects of renin–angiotensin system blockade on the islet morphology and function in rats with long-term high-fat diet

L Yuan, X Li, J Li, H Li, S Cheng - Acta Diabetologica, 2013 - Springer
The renin–angiotensin system (RAS) has an important role in the endocrine pancreas.
Multiple researches have shown that even in the insulin resistance phase, there are many …

Angiotensin‐converting enzyme 2 deficiency aggravates glucose intolerance via impairment of islet microvascular density in mice with high‐fat diet

L Yuan, Y Wang, C Lu, X Li - Journal of diabetes research, 2013 - Wiley Online Library
The aim of this study was to evaluate the effects of angiotensin‐converting enzyme 2 (ACE2)
on glucose homeostasis and islet function in mice. Male wildtype (WT) and ACE2 knockout …

Diabetes and renin-angiotensin-aldosterone system: pathophysiology and genetics

A Nabi, A Ebihara - Renin-Angiotensin Aldosterone System, 2021 - books.google.com
Diabetes mellitus (DM) is a metabolic disorder and characterized by hyperglycemia. Being a
concern of both the developed and developing world, diabetes is a global health burden …