Backgrounds Genome-wide association studies have identified multiple genetic variants
associated with obesity. However, most obesity-associated loci were waiting to be translated …

People with excess weight (overweight or obese; body mass index [BMI]> 25) are generally
characterized as impulsive with regards to food. However, the underlying brain mechanisms …

Perineuronal nets (PNNs) are specialized extracellular matrix structures that primarily
surround fast-spiking parvalbumin (PV)-containing interneurons within the PFC. They …

Individuals with substance use problems show lower executive control and alterations in
prefrontal brain systems supporting emotion regulation and impulse control. A separate …

Binge eating disorder is the most common eating disorder and therefore an important health
problem worldwide often resulting in obesity. Current investigations on binge eating …

The main aim of this study was to explore the association between overweight/obesity and
executive control (EC) in young adults, and to further analyze the mediating effect of brain …

The chronic consumption of caloric dense high-fat foods is a major contributor to increased
body weight, obesity, and other chronic health conditions. The orbitofrontal cortex (OFC) is …

Binge eating is characterized as eating a large amount of food and feeling a loss of control
while eating. However, the neurobiological mechanisms associated with the onset and …

Background: The ageing of the population is a global challenge and the period of life spent
in good health, although increasing, is not keeping pace with lifespan. Consequently …

Objective Prior studies have suggested reciprocal relationships between cognitive function
and adiposity, but this has not been investigated with population representative data sets …