Conclusions The current treatment of RA does not provide acceptable control of the
inflammatory process due to either the onset of adverse effects or the lack of efficacy. RA is a …

Rheumatoid arthritis is a chronic immune-mediated disease characterised by an
inflammatory synovitis and extra-articular manifestations. There is an expanding body of …

Although numerous experimentat immunomodulalory regimens have been reported to be
effective in the treatment of rheumatoid arthritis, they also produce undesirable side effects …

Six patients with rheumatoid arthritis were treated with a CD7 mouse monoclonal antibody,
RFT2, daily for 14 days. Only two patients had a significant improvement in clinical disease …

There is now evidence that T lymphocytes, in particular the CD4+ subset, are important in
the initiation and maintenance of rheumatoid inflammation.'2 Treatment with non-specific …

Rheumatoid arthritis (RA) is characterised by a chronic inflammatory polyarthritis that can
involve any synovial joint. It affects 1-3% of the population and is characterised by erosive …

Severe attacks of ulcerative colitis are medical emergencies, and surgical treatment is
indicated when glucocorticoid therapy is not effective. We have carried out an open clinical …

Cyclosporin A (SandimmunR) has gained wide acceptance by most transplant physicians as
the immuno-suppressant of choice for preventing rejection of solid organ grafts and graft …

Current theories of the aetiology of RA point to a central role for the trimolecular complex
comprising the MHC class II molecule on the surface of the APC, the antigenic peptide and …

The present invention provides peptides which affect T-cells, presumably by action on the T-
cell antigen receptor. The present invention further relates to the therapy of various …