An accelerating basic science literature is providing key insights into the mechanisms by
which spinal neuropeptide Y (NPY) inhibits chronic pain. A key target of pain inhibition is the …

Endogenous neuropeptide Y (NPY) exerts long-lasting spinal inhibitory control of
neuropathic pain, but its mechanism of action is complicated by the expression of its …

Research during the past two decades supports a complex role for neuropeptide tyrosine
(NPY) and two of its associated receptors, the Y 1 receptor and the Y 2 receptor, in the …

Primary sensory neurons in the dorsal root ganglia and trigeminal ganglia are responsible
for sensing mechanical and thermal stimuli, as well as detecting tissue damage. These …

Our previous work indicates that the intrathecal administration of neuropeptide Y (NPY) acts
at its cognate receptors to reduce behavioral signs of nociception in several models of …

Of all clinically marketed drugs, greater than thirty percent are modulators of G protein–
coupled receptors (GPCRs). Nearly 400 GPCRs (ie, excluding odorant and light receptors) …

The complex life cycle and immunopathological features underpinning the interaction of
Leishmania parasites and their mammalian hosts poses frequent poorly explored and …

Nerve injury increases the spinal cord expression and/or activity of voltage-and ligand-gated
ion channels, peptide receptors, and neuroimmune factors, which then drive dorsal horn …

Neuropeptide tyrosine (neuropeptide Y [NPY]) is widely expressed in the CNS and
peripheral nervous systems and has been shown to have a role in numerous physiologic …

Sickle cell disease (SCD) is an inherited blood disorder associated with significant
morbidity, which includes severe episodic pain, and, often, chronic pain. Compared to …