Huntington's disease (HD) is a monogenic inherited polyglutamine-mediated
neurodegenerative disorder for which effective therapies are currently unavailable …

Arcuate nucleus (ARC) pro-opiomelanocortin (POMC) neurons are essential regulators of
food intake, energy expenditure, and glucose homeostasis. POMC neurons integrate …

Altered levels of colonic peptide YY (PYY) have been reported in patients suffering from
functional and inflammatory bowel disorders. While the involvement of neuropeptide Y …

Neuropeptide tyrosine (NPY) and its associated receptors Y1R and Y2R have been
previously implicated in the spinal modulation of neuropathic pain induced by total or partial …

Lumbar intrathecal injection of neuropeptide Y (NPY) is antinociceptive, particularly in
models of nerve injury and inflammation. Intrathecal NPY does not alter nociception in mice …

Neuropeptide Y (NPY) has an important but still insufficiently defined role in pain
modulation. We therefore examined the ability of NPY to modulate experimentally induced …

Single ligature nerve constriction (SLNC) is a newly developed animal model for the study of
neuropathic pain. SLNC of the rat sciatic nerve induces pain-related behaviors, as well as …

OBJECTIVE: Recent pharmacologic studies in our laboratory have suggested that the spinal
neuropeptide Y (NPY) Y1 receptor contributes to pain inhibition and to the analgesic effects …

Neuropeptide Y signaling plays an important role in inhibiting chronic pain in the spinal cord
of mice. However, little is known about the respective roles of two major neuropeptide Y …

Itch is a somatosensory sensation to remove potential harmful stimulation with a scratching
desire, which could be divided into mechanical and chemical itch according to diverse …