Itch is a somatosensory sensation to remove potential harmful stimulation with a scratching
desire, which could be divided into mechanical and chemical itch according to diverse …

OBJECTIVE: Recent pharmacologic studies in our laboratory have suggested that the spinal
neuropeptide Y (NPY) Y1 receptor contributes to pain inhibition and to the analgesic effects …

Single ligature nerve constriction (SLNC) of the rat sciatic nerve triggers neuropathic pain-
related behaviors and induces changes in neuropeptide expression in primary afferent …

Neuropeptide Y (NPY) modulates nociception in the spinal cord, but little is known about its
mechanisms of release. We measured NPY release in situ using the internalization of its Y1 …

Background: Unilateral constrictive sciatic nerve injury (uCCI) is a common neuropathic pain
model. However, the bilateral constrictive injury (bCCI) model is less well studied, and …

Although morphine is a potent antinociceptive agent, its chronic use developed tolerance in
neuropathic pain (NP). Furthermore, opioid antagonist naloxone attenuated the …

Background Previous studies found that rats subjected to carrageenan injection develop
hyperalgesia, and despite complete recovery in several days, they continue to have an …

Ilex paraguariensis, known as “Yerba Mate,” is an herb used in a beverage that is widely
consumed in southern Latin American countries. Furthermore, it has been traditionally used …

We used a new computer-assisted method to precisely localize and efficiently quantify
increases in neuropeptide Y immunoreactivity (NPY-ir) along the mediolateral axis of the L4 …

Cellular mechanisms of antinociceptive action of neuropeptide Y were investigated in
substantia gelatinosa (SG) neurons in rat spinal cord slices. Somatic and synaptic effects of …