For complex diseases, most drugs are highly ineffective, and the success rate of drug
discovery is in constant decline. While low quality, reproducibility issues, and translational …

A link between oxidative stress and hypertension has been firmly established in multiple
animal models of hypertension but remains elusive in humans. While initial studies focused …

As a major cause of morbidity and mortality globally, hypertension remains a serious threat
to global public health. Despite the availability of many antihypertensive medications …

The development of essential hypertension involves several factors. Vascular dysfunction,
characterized by endothelial dysfunction, low-grade inflammation and structural remodeling …

Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases regulate production of
reactive oxygen species (ROS) that cause oxidative damage to cellular components but also …

Mechanism-based therapy centred on the molecular understanding of disease-causing
pathways in a given patient is still the exception rather than the rule in medicine, even in …

Hypertension is a leading risk factor for stroke, heart disease and chronic kidney disease.
Multiple interacting factors and organ systems increase blood pressure and cause target …

Oxidative stress within the vascular endothelium, due to excess generation of reactive
oxygen species (ROS), is thought to be fundamental to the initiation and progression of the …

Atherosclerosis and its complications are major causes of cardiovascular morbidity and
death. Apart from risk factors such as hypercholesterolemia and inflammation, the causal …

Background: Acute kidney injury (AKI) induced by renal ischemia-reperfusion injury (RIRI) is
associated with a high incidence of mortality. Existing therapies are mainly supportive, with …