Major depressive disorder (MDD) is characterized by persistent depressed mood, loss of
interest or pleasure in previously enjoyable activities, recurrent thoughts of death, and …

Psychedelics make up a group of psychoactive compounds that induce hallucinogenic
effects by activating the serotonin 2A receptor (5-HT2AR). Clinical trials have demonstrated …

Gene-environment interactions shape behavior and susceptibility to depression. However,
little is known about the signaling pathways integrating genetic and environmental inputs to …

Major depressive disorder is a global psychiatric condition characterized by persistent low
mood and anhedonia, which seriously jeopardizes the physical and mental well-being of …

Background Major depressive disorder (MDD) is highly recurrent. Identifying risk factors for
relapse in depression is essential to improve prevention plans and therapeutic outcomes …

Psychiatric and neurodegenerative disorders are amongst the most prevalent and
debilitating diseases, but current treatments either have low success rates, greatly due to the …

Neuropsychiatric disorders, which are associated with stress hormone dysregulation, occur
at different rates in men and women. Moreover, nowadays, preclinical and clinical evidence …

Introduction Treatment-resistant depression (TRD) is a serious and debilitating psychiatric
disorder that frequently affects older patients. Esketamine nasal spray (ESK-NS) has …

Microglia are so versatile that they not only provide immune surveillance for central nervous
system, but participate in neural circuitry development, brain blood vessels formation, blood …

The growing interest in the rapid and sustained antidepressant effects of the dissociative
anesthetic ketamine and classic psychedelics, such as psilocybin, is remarkable. However …