Aging is a gradual and irreversible pathophysiological process. It presents with declines in
tissue and cell functions and significant increases in the risks of various aging-related …

Damage or loss of brain cells and impaired neurochemistry, neurogenesis, and synaptic and
nonsynaptic plasticity of the brain lead to dementia in neurodegenerative diseases, such as …

Alzheimer's disease (AD) is the most common cause for dementia worldwide. Until recently,
all approved treatments for AD were symptomatic and not disease modifying. On 7 June …

Advancing age is one of the risk factors for developing many diseases, including cancer,
cardiovascular disorders, and neurodegenerative alterations, such as mild cognitive …

Alzheimer's disease (AD) is one of the most devastating brain disorders. Currently, there are
no effective treatments to stop the disease progression and it is becoming a major public …

A decrease in the activity of the insulin signaling system of the brain, due to both central
insulin resistance and insulin deficiency, leads to neurodegeneration and impaired …

Mirtazapine belongs to the category of antidepressants clinically used mainly in major
depressive disorder but also used in obsessive-compulsive disorders, generalized anxiety …

Alzheimer's disease (AD) is the main cause of dementia worldwide. Emerging non-invasive
treatments such as photobiomodulation target the mitochondria to minimize brain damage …

A major obstacle to progress in understanding the etiology of normative and pathological
human brain aging is the availability of suitable animal models for experimentation. The …

Clinical trials show that insulin administered intranasally is a promising drug to treat
neurodegenerative diseases, but at high doses its use may result in cerebral insulin …