BACKGROUND Advanced maternal age is associated with decreased oocyte quantity and
quality as well as uterine and placental dysfunctions. These changes lead to infertility …

Mitochondrial dysfunction is one of the hallmarks of aging. Consistently mitochondrial DNA
(mtDNA) copy number and function decline with age in various tissues. There is increasing …

Background It is reported that growth hormone (GH) can alleviate oxidative stress (OS)
induced apoptosis in some types of cells by activating the PI3K/Akt signaling pathway. This …

The increased demands and dependence on depleted oil reserves, accompanied by global
warming and climate change have driven the world to explore and develop new strategies …

Proper physiological function of the ovaries is very important for the entire female
reproductive system and overall health. Reactive oxygen species (ROS) are generated as …

Abstract Peroxiredoxin 4 (Prdx4), a member of the Prdx family, is a vital ER-resident
antioxidant in cells. As revealed in our previous study, Prdx4 expression was detected in …

Oxidative stress (OS) plays an important role in a variety of physiological and pathological
processes of the female reproductive system. In recent years the relationship between OS …

Polycystic ovary syndrome (PCOS) is a heterogeneous functional endocrine disorder
associated with a low-grade, chronic inflammatory state. Patients with PCOS present an …

Diseases of postpartum dairy cows impair reproductive processes, resulting in prolonged
anestrus, reduced conception, and increased pregnancy attrition, regardless of whether the …

The number of mitochondria in the oocyte along with their functions (eg, energy production,
scavenger activity) decline with age progression. Such multifaceted functions support …