Adoptive cell therapy (ACT) is rapidly migrating from bench to clinical therapy for
hematological malignancies. Recently, a new subtype of memory T cells, stem cell memory …

Downregulation of the T cell system has been proposed as a mechanism to block immunity
in colonic cancer (CC). However, little has been studied about circulating αβ and γδ T cells …

Background T regulatory cell (Treg) plays a critical role in respiratory allergy and allergen-
specific immunotherapy (SIT), and γδ T cells might participate in mediating Treg quantity …

A previous study has demonstrated a significant decrease in the TCRζ gene expression
level in chronic myeloid leukemia (CML); thus, we further investigated the expression of …

Abstract Background The Notch signaling pathway is crucial in T-cell development, Notch 1
mutations are frequently present in T-cell acute lymphoblastic leukemia (T-ALL). To …

Background Aplastic anemia (AA) is characterized by pancytopenia and bone marrow
hypoplasia, which results from immune-mediated hematopoiesis suppression …

Defective T cell receptor (TCR) signaling resulting in lower T cell function plays a crucial role
in the pathogenesis of T cell immunodeficiency in leukemia. Previous studies have indicated …

Wiskott‑Aldrich syndrome protein family member 3 (WASF3) is required for invasion and
metastasis in different cancer cell types, and has been demonstrated to possess prognostic …

In leukemia patients, T-cell function has been suppressed with the disease progress.
Patients with chronic lymphocytic leukemia (CLL) are all to a degree immunodeficient. In …

T-cell immunodeficiency is a common feature in patients with chronic myeloid leukemia
(CML), and deficiency in CD3 levels was detected in T cells from these patients, which may …