Chronic spontaneous urticaria: focus on pathophysiology to unlock treatment advances

A Kaplan, M Lebwohl, AM Giménez‐Arnau, M Hide… - Allergy, 2023 - Wiley Online Library
Chronic spontaneous urticaria (CSU) is a debilitating skin disease characterized by
intensely itchy wheals, angioedema, or both. Symptoms recur spontaneously, on a near …

The pathogenesis of chronic spontaneous urticaria: the role of infiltrating cells

AM Giménez-Arnau, L de Montjoye, R Asero… - The Journal of Allergy …, 2021 - Elsevier
Chronic spontaneous urticaria is characterized by a perivascular non-necrotizing cellular
infiltrate around small venules of the skin. It consists primarily of CD4 (+) lymphocytes, a …

[HTML][HTML] Chronic spontaneous urticaria after BNT162b2 mRNA (Pfizer-BioNTech) vaccination against SARS-CoV-2

E Magen, A Yakov, I Green, A Israel… - Allergy and Asthma …, 2022 - ncbi.nlm.nih.gov
Background: The factors that trigger and exacerbate chronic spontaneous urticaria (CSU)
are well known, but it is not unclear whether messenger RNA (mRNA) vaccination against …

How to treat patients with chronic spontaneous urticaria with omalizumab: questions and answers

M Türk, L Carneiro-Leão, P Kolkhir, H Bonnekoh… - The Journal of Allergy …, 2020 - Elsevier
Omalizumab is an effective treatment for patients with chronic spontaneous urticaria (CSU).
In routine clinical practice, physicians often face complex cases of CSU and need to decide …

COVID-19 disease leading to chronic spontaneous urticaria exacerbation: a Romanian retrospective study

IA Muntean, I Pintea, IC Bocsan, CT Dobrican… - Healthcare, 2021 - mdpi.com
(1) Background: The COVID-19 pandemic has resulted in the exacerbation of various
chronic diseases. Due to the potential impact of SARS-CoV-2 on mast cells, we aimed to …

Urticaria and angioedema across the ages

S Saini, M Shams, JA Bernstein, M Maurer - The Journal of Allergy and …, 2020 - Elsevier
Chronic urticaria (CU) and angioedema can occur at any age. Although most CU with or
without angioedema occurs in adults, it can also present in children or the elderly and can …

Increased platelet activating factor levels in chronic spontaneous urticaria predicts refractoriness to antihistamine treatment: an observational study

B Ulambayar, EM Yang, HY Cha, YS Shin… - Clinical and translational …, 2019 - Springer
Background Platelet activating factor (PAF) is an endogenous, active phospholipid released
from inflammatory cells, platelets, and endothelial cells, and is involved in the regulation of …

Omalizumab for Patients with Chronic Spontaneous Urticaria: A Narrative Review of Current Status

TB Casale, AM Gimenez-Arnau, JA Bernstein… - Dermatology and …, 2023 - Springer
Chronic spontaneous urticaria (CSU) is a debilitating inflammatory disorder of the skin,
characterized by a fluctuating natural history, a complex mechanism of action, and a …

Existing and investigational medications for refractory chronic spontaneous urticaria: safety, adverse effects, and monitoring

E Kocaturk, SS Saini, CJ Rubeiz… - The Journal of Allergy and …, 2022 - Elsevier
Treatment of chronic spontaneous urticaria (CSU) is responsive to H1 antihistamines
administered up to four times the recommended US Food and Drug Administration dose in …

Biomarkers in chronic spontaneous urticaria: current targets and clinical implications

I Puxeddu, F Petrelli, F Angelotti, C Croia… - Journal of asthma and …, 2019 - Taylor & Francis
Chronic urticaria (CU) is a mast cell-driven disease characterized by the development of
wheals, angioedema, or both for more than 6 weeks. The two major sub-types are chronic …