Production of mature mRNAs that encode functional proteins consists of a highly complex
pathway of synthesis, processing and export. Along this pathway, the mRNA transcript is …

Post-transcriptional events in the life of an RNA including RNA processing, transport,
translation and metabolism are characterized by the regulated assembly of multiple …

We have developed an inducible system to visualize gene expression at the levels of DNA,
RNA and protein in living cells. The system is composed of a 200 copy transgene array …

Metazoan physiology depends on intricate patterns of gene expression that remain poorly
known. Using transposon mutagenesis in Drosophila, we constructed a library of 7404 …

The carboxy-terminal domain (CTD) of the RNA polymerase II (RNApII) largest subunit
consists of multiple heptapeptide repeats with the consensus sequence YSPTSPS. Different …

RNA‐binding proteins HuR and AUF1 bind to many common AU‐rich target mRNAs and
exert opposing influence on target mRNA stability, but the functional interactions between …

The conserved core of the exosome, the major eukaryotic 3′→ 5′ exonuclease, contains
nine subunits that form a ring similar to the phosphorolytic bacterial PNPase and archaeal …

Zinc-finger antiviral protein (ZAP) is a host antiviral factor that specifically inhibits the
replication of Moloney murine leukemia virus (MLV) and Sindbis virus (SIN) by preventing …

Spt6 promotes transcription elongation at many genes and functions as a histone H3
chaperone to alter chromatin structure during transcription. We show here that mammalian …

Many steps in gene expression and mRNA biosynthesis are coupled to transcription
elongation and organized through the C-terminal domain (CTD) of the large subunit of RNA …