[HTML][HTML] Neurogenesis from embryo to adult–lessons from flies and mice

H Mira, J Morante - Frontiers in Cell and Developmental Biology, 2020 - frontiersin.org
The human brain is composed of billions of cells, including neurons and glia, with an
undetermined number of subtypes. During the embryonic and early postnatal stages, the …

Adding a spatial dimension to postnatal ventricular-subventricular zone neurogenesis

R Fiorelli, K Azim, B Fischer, O Raineteau - Development, 2015 - journals.biologists.com
Neurogenesis does not stop abruptly at birth, but persists in specific brain regions
throughout life. The neural stem cells (NSCs) located in the largest germinal region of the …

[PDF][PDF] Single-cell analysis of regional differences in adult V-SVZ neural stem cell lineages

D Mizrak, HM Levitin, AC Delgado, V Crotet, J Yuan… - Cell reports, 2019 - cell.com
The ventricular-subventricular zone (V-SVZ) harbors adult neural stem cells. V-SVZ neural
stem cells exhibit features of astrocytes, have a regional identity, and depending on their …

Single-cell analysis of the postnatal dorsal V-SVZ reveals a role for Bmpr1a signaling in silencing pallial germinal activity

G Marcy, L Foucault, E Babina, T Capeliez… - Science …, 2023 - science.org
The ventricular-subventricular zone (V-SVZ) is the largest neurogenic region of the postnatal
forebrain, containing neural stem cells (NSCs) that emerge from both the embryonic pallium …

Quiescent neural stem cells for brain repair and regeneration: lessons from model systems

L Otsuki, AH Brand - Trends in Neurosciences, 2020 - cell.com
Neural stem cells (NSCs) are multipotent progenitors that are responsible for producing all
of the neurons and macroglia in the nervous system. In adult mammals, NSCs reside …

[PDF][PDF] Persistent expression of VCAM1 in radial glial cells is required for the embryonic origin of postnatal neural stem cells

XL Hu, G Chen, S Zhang, J Zheng, J Wu, QR Bai… - Neuron, 2017 - cell.com
During development, neural stem cells (NSCs) undergo transitions from neuroepithelial cells
to radial glial cells (RGCs), and later, a subpopulation of slowly dividing RGCs gives rise to …

Pharmacogenomic identification of small molecules for lineage specific manipulation of subventricular zone germinal activity

K Azim, D Angonin, G Marcy, F Pieropan, A Rivera… - PLoS …, 2017 - journals.plos.org
Strategies for promoting neural regeneration are hindered by the difficulty of manipulating
desired neural fates in the brain without complex genetic methods. The subventricular zone …

[PDF][PDF] HOPX defines heterogeneity of postnatal subventricular zone neural stem cells

S Zweifel, G Marcy, QL Guidice, D Li, C Heinrich… - Stem cell reports, 2018 - cell.com
The largest diversity of neural lineages generated from the subventricular zone (SVZ) occurs
early after birth and is regulated in a spatiotemporal manner depending on the expression of …

Neural stem cells in the adult olfactory bulb core generate mature neurons in vivo

Ç Defteralı, M Moreno-Estellés, C Crespo… - Stem Cells, 2021 - academic.oup.com
Although previous studies suggest that neural stem cells (NSCs) exist in the adult olfactory
bulb (OB), their location, identity, and capacity to generate mature neurons in vivo has been …

Targeting the subventricular zone to promote myelin repair in the aging brain

AM Butt, AD Rivera, D Fulton, K Azim - Cells, 2022 - mdpi.com
The subventricular zone (SVZ) is the largest and most active germinal zone in the adult
forebrain. Neural stem cells (NSCs) of the SVZ generate olfactory interneurons throughout …