Nearly half a century has passed since the discovery of cytoplasmic inheritance of human
chloramphenicol resistance. The inheritance was then revealed to take place maternally by …

Mitochondrial dysfunction is strongly implicated in the etiology of idiopathic and genetic
Parkinson's disease (PD). However, strategies aimed at ameliorating mitochondrial …

Microglia and neuroinflammation play an important role in the development and progression
of Alzheimer's disease (AD). Inositol polyphosphate-5-phosphatase D (INPP5D/SHIP1) is a …

Maintenance of mitochondrial health is essential for neuronal survival and relies upon
dynamic changes in the mitochondrial network and effective mitochondrial quality control …

Many different intrinsically disordered proteins and proteins with intrinsically disordered
regions are associated with neurodegenerative diseases. These types of proteins including …

Nonalcoholic steatohepatitis (NASH) is closely related to liver fibrosis. The role of coiled-coil-
helix-coiled-coil-helix domain-containing 2 (CHCHD2) in NASH remains unknown …

Parkinson's disease (PD) is the second-most prevalent neurodegenerative disorder,
characterized by the loss of dopaminergic neurons (mDA) in the midbrain. The underlying …

Abstract The p. Thr61Ile (p. T61I) mutation in coiled‐coil‐helix–coiled‐coil‐helix domain
containing 2 (CHCHD2) was deemed a causative factor in Parkinson's disease (PD) …

Parkinson's disease (PD) is a common neurodegenerative disorder that results from the loss
of dopaminergic neurons. Mutations in coiled‐coil‐helix‐coiled‐coil‐helix domain …

Mitochondria are essential for neuronal survival and mitochondrial dysfunction is a hallmark
of neurodegeneration. The loss in mitochondrial energy production, oxidative stress, and …