Integrins are considered the main cell-adhesion transmembrane receptors that play
multifaceted roles as extracellular matrix (ECM)-cytoskeletal linkers and transducers in …

The smooth muscle cell directly drives the contraction of the vascular wall and hence
regulates the size of the blood vessel lumen. We review here the current understanding of …

Forces that are associated with blood flow are major determinants of vascular
morphogenesis and physiology. Blood flow is crucial for blood vessel development during …

Mechanical forces are crucial to the regulation of cell and tissue morphology and function. At
the cellular level, forces influence cytoskeletal organization, gene expression, proliferation …

A growing body of data supports a view of the actin cytoskeleton of smooth muscle cells as a
dynamic structure that plays an integral role in regulating the development of mechanical …

The diameter of resistance arteries has a profound effect on the distribution of microvascular
blood flow and the control of systemic blood pressure. Here, we review mechanisms that …

The extracellular matrix plays a critical role in orchestrating the events necessary for wound
healing, muscle repair, morphogenesis, new blood vessel growth, and cancer invasion. In …

The fibrous collagens form the structural basis of all mammalian connective tissues,
including the vasculature, dermis, bones, tendons, cartilage, and those tissues that support …

Many studies reveal a fundamental role for extracellular matrix-mediated signaling through
integrins and Rho GTPases as well as matrix metalloproteinases (MMPs) in the molecular …

This review focuses on the neurobiology of integrins, pathophysiological roles of integrins in
neuroplasticity and nervous system disorders, and therapeutic implications of integrins as …