Insulin-like Growth Factor (IGF)/IGF-1 Receptor (IGF-1R) signaling is known to regulate stem
cell pluripotency and differentiation to trigger cell proliferation, organ development, and …

The Hippo signaling pathway is widely considered a master regulator of organ growth
because of the prominent overgrowth phenotypes caused by experimental manipulation of …

The MST/Hippo signalling pathway was first described over a decade ago in Drosophila
melanogaster and the core of the pathway is evolutionary conserved in mammals. The …

The optic vesicle comprises a pool of bi-potential progenitor cells from which the retinal
pigment epithelium (RPE) and neural retina fates segregate during ocular morphogenesis …

Yap functions as a transcriptional regulator by acting together with sequence-specific DNA
binding factors and transcription cofactors to mediate cell proliferation in developing …

The adult frog retina retains a reservoir of active neural stem cells that contribute to
continuous eye growth throughout life. We found that Yap, a downstream effector of the …

ABSTRACT The Hippo‐Yes associated protein (Yap) pathway plays an important role in
organ size control by regulating cell proliferation, apoptosis, and stem cell renewal. Hippo …

The Hippo pathway regulates myriad biological processes in diverse species and is a key
cancer signaling network in humans. Although Hippo has been linked to multiple aspects of …

The evolutionarily conserved Hippo signaling pathway is known to regulate cell proliferation
and maintain tissue homeostasis during development. We found that activation of Yorkie …

Hippo signaling is a critical pathway that integrates extrinsic and intrinsic mechanical cues to
regulate organ size. Despite its essential role in organogenesis, little is known about its role …