The role of IGF/IGF-1R signaling in hepatocellular carcinomas: stemness-related properties and drug resistance

MHT Ngo, HY Jeng, YC Kuo, JD Nanda… - International journal of …, 2021 - mdpi.com
Insulin-like Growth Factor (IGF)/IGF-1 Receptor (IGF-1R) signaling is known to regulate stem
cell pluripotency and differentiation to trigger cell proliferation, organ development, and …

Hippo signaling instructs ectopic but not normal organ growth

W Kowalczyk, L Romanelli, M Atkins, H Hillen… - Science, 2022 - science.org
The Hippo signaling pathway is widely considered a master regulator of organ growth
because of the prominent overgrowth phenotypes caused by experimental manipulation of …

The MST/Hippo pathway and cell death: a non-canonical affair

E Fallahi, NA O'Driscoll, D Matallanas - Genes, 2016 - mdpi.com
The MST/Hippo signalling pathway was first described over a decade ago in Drosophila
melanogaster and the core of the pathway is evolutionary conserved in mammals. The …

Yap and Taz regulate retinal pigment epithelial cell fate

JB Miesfeld, G Gestri, BS Clark, MA Flinn… - …, 2015 - journals.biologists.com
The optic vesicle comprises a pool of bi-potential progenitor cells from which the retinal
pigment epithelium (RPE) and neural retina fates segregate during ocular morphogenesis …

Combined inactivation of RB and Hippo converts differentiating Drosophila photoreceptors into eye progenitor cells through derepression of homothorax

AE Rader, B Bayarmagnai, MV Frolov - Developmental Cell, 2023 - cell.com
The retinoblastoma (RB) and Hippo pathways interact to regulate cell proliferation and
differentiation. However, the mechanism of interaction is not fully understood. Drosophila …

[HTML][HTML] Yap is essential for retinal progenitor cell cycle progression and RPE cell fate acquisition in the developing mouse eye

JY Kim, R Park, JHJ Lee, J Shin, J Nickas, S Kim… - Developmental …, 2016 - Elsevier
Yap functions as a transcriptional regulator by acting together with sequence-specific DNA
binding factors and transcription cofactors to mediate cell proliferation in developing …

Hippo‐yap signaling in ocular development and disease

M Lee, N Goraya, S Kim, SH Cho - Developmental Dynamics, 2018 - Wiley Online Library
ABSTRACT The Hippo‐Yes associated protein (Yap) pathway plays an important role in
organ size control by regulating cell proliferation, apoptosis, and stem cell renewal. Hippo …

YAP controls retinal stem cell DNA replication timing and genomic stability

P Cabochette, G Vega-Lopez, J Bitard, K Parain… - elife, 2015 - elifesciences.org
The adult frog retina retains a reservoir of active neural stem cells that contribute to
continuous eye growth throughout life. We found that Yap, a downstream effector of the …

The Hippo pathway as a driver of select human cancers

A Kulkarni, MT Chang, JHA Vissers, A Dey, KF Harvey - Trends in cancer, 2020 - cell.com
The Hippo pathway regulates myriad biological processes in diverse species and is a key
cancer signaling network in humans. Although Hippo has been linked to multiple aspects of …

Protein Phosphatase 2A with B′ specificity subunits regulates the Hippo-Yorkie signaling axis in the Drosophila eye disc

SJ Neal, Q Zhou, F Pignoni - Journal of Cell Science, 2022 - journals.biologists.com
ABSTRACT Hippo-Yorkie (Hpo-Yki) signaling is central to diverse developmental
processes. Although its redeployment has been amply demonstrated, its context-specific …