Serotonergic system, cognition, and BPSD in Alzheimer's disease

S Chakraborty, JC Lennon, SA Malkaram, Y Zeng… - Neuroscience …, 2019 - Elsevier
Abstract Behavioral and Psychological Symptoms of Dementia (BPSD), present in almost
90% of patients with Alzheimer's Disease (AD), cause extensive impairment leading to …

Gestational factors throughout fetal neurodevelopment: the serotonin link

SI Hanswijk, M Spoelder, L Shan, MMM Verheij… - International journal of …, 2020 - mdpi.com
Serotonin (5-HT) is a critical player in brain development and neuropsychiatric disorders.
Fetal 5-HT levels can be influenced by several gestational factors, such as maternal …

Classical hallucinogens as antidepressants? A review of pharmacodynamics and putative clinical roles

D Baumeister, G Barnes, G Giaroli… - Therapeutic Advances …, 2014 - journals.sagepub.com
Hallucinogens have been part of spiritual practice for millennia, but controversy surrounding
their mind-manifesting effects led to their proscription by the mid-20th century, largely …

Monoamine-sensitive developmental periods impacting adult emotional and cognitive behaviors

D Suri, CM Teixeira, MKC Cagliostro… - …, 2015 - nature.com
Abstract Development passes through sensitive periods, during which plasticity allows for
genetic and environmental factors to exert indelible influence on the maturation of the …

Bisphenol A, bisphenol F and bisphenol S affect differently 5α-reductase expression and dopamine–serotonin systems in the prefrontal cortex of juvenile female rats

B Castro, P Sánchez, JM Torres, E Ortega - Environmental research, 2015 - Elsevier
Background Early-life exposure to the endocrine disruptor bisphenol A (BPA) affects brain
function and behavior, which might be attributed to its interference with hormonal steroid …

Postnatal day 2 to 11 constitutes a 5-HT-sensitive period impacting adult mPFC function

TJ Rebello, Q Yu, NM Goodfellow… - Journal of …, 2014 - Soc Neuroscience
Early-life serotonin [5-hydroxytryptamine (5-HT)] signaling modulates brain development,
which impacts adult behavior, but 5-HT-sensitive periods, neural substrates, and behavioral …

Serotonin limits generation of chromaffin cells during adrenal organ development

P Kameneva, VI Melnikova, ME Kastriti… - Nature …, 2022 - nature.com
Adrenal glands are the major organs releasing catecholamines and regulating our stress
response. The mechanisms balancing generation of adrenergic chromaffin cells and …

Fluoxetine normalizes the effects of prenatal maternal stress on depression-and anxiety-like behaviors in mouse dams and male offspring

AA Salari, L Fatehi-Gharehlar, N Motayagheni… - Behavioural brain …, 2016 - Elsevier
Maternal depression during pregnancy and the postpartum period (lactation) is a common
debilitating condition affecting mother-fetus/-infant interactions, which can be a risk factor for …

The neurodevelopmental effects of serotonin: a behavioural perspective

LJ Kepser, JR Homberg - Behavioural brain research, 2015 - Elsevier
Serotonin is well known for its role in psychiatric disorders like depression and autism, but it
is less clear how aberrant behaviour associated with these disorders are shaped by …

Integrative multi-omics landscape of fluoxetine action across 27 brain regions reveals global increase in energy metabolism and region-specific chromatin remodelling

NA Rayan, V Kumar, J Aow, N Rastegar, MGL Lim… - Molecular …, 2022 - nature.com
Depression and anxiety are major global health burdens. Although SSRIs targeting the
serotonergic system are prescribed over 200 million times annually, they have variable …