Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection often causes
severe complications and even death. However, asymptomatic infection has also been …

B cell acute lymphoblastic leukaemia (B-ALL) is the most common form of childhood cancer.
Although treatment has advanced remarkably in the past 50 years, it still fails in~ 20% of …

The E26 transformation specific (ETS) family comprises 28 transcription factors, the majority
of which are involved in tumor initiation and development. Serving as a group of functionally …

We have recently reported that some cancers induce accumulation of bone marrow (BM) B-
cell precursors in the spleen to convert them into metastasis-promoting, immunosuppressive …

CRISPR technologies have advanced cancer modelling in mice, but CRISPR activation
(CRISPRa) methods have not been exploited in this context. We establish a CRISPRa …

Despite advances in single-cell multi-omics, a single stem or progenitor cell can only be
tested once. We developed clonal multi-omics, in which daughters of a clone act as …

Distal enhancers play critical roles in sustaining oncogenic gene-expression programs. We
identify aberrant enhancer-like activation of GGAA tandem repeats as a characteristic …

Maternal obesity adversely impacts the in utero metabolic environment, but its effect on fetal
hematopoiesis remains incompletely understood. During late development, the fetal bone …

Philadelphia chromosome–positive B cell acute lymphoblastic leukemia (B-ALL),
characterized by the BCR:: ABL1 fusion gene, remains a poor prognosis cancer needing …

Regeneration of functional B lymphopoiesis from pluripotent stem cells (PSCs) is
challenging, and reliable methods have not been developed. Here, we unveiled the guiding …