Cardiac fibrosis: Myofibroblast-mediated pathological regulation and drug delivery strategies

M Liu, BL de Juan Abad, K Cheng - Advanced drug delivery reviews, 2021 - Elsevier
Cardiac fibrosis remains an unresolved problem in heart diseases. After initial injury, cardiac
fibroblasts (CFs) are activated and subsequently differentiate into myofibroblasts (myoFbs) …

Peroxisome proliferator-activated receptors and their novel ligands as candidates for the treatment of non-alcoholic fatty liver disease

A Fougerat, A Montagner, N Loiseau, H Guillou… - Cells, 2020 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is a major health issue worldwide, frequently
associated with obesity and type 2 diabetes. Steatosis is the initial stage of the disease …

Recent Insights on the Role of PPAR-β/δ in Neuroinflammation and Neurodegeneration, and Its Potential Target for Therapy

AK Strosznajder, S Wójtowicz, MJ Jeżyna… - Neuromolecular …, 2021 - Springer
Peroxisome proliferator-activated receptor (PPAR) β/δ belongs to the family of hormone and
lipid-activated nuclear receptors, which are involved in metabolism of long-chain fatty acids …

Energy substrate metabolism and oxidative stress in metabolic cardiomyopathy

Z Chen, ZX Jin, J Cai, R Li, KQ Deng, YX Ji… - Journal of Molecular …, 2022 - Springer
Metabolic cardiomyopathy is an emerging cause of heart failure in patients with obesity,
insulin resistance, and diabetes. It is characterized by impaired myocardial metabolic …

[HTML][HTML] Ginsenoside Rb3 regulates energy metabolism and apoptosis in cardiomyocytes via activating PPARα pathway

X Chen, Q Wang, M Shao, L Ma, D Guo, Y Wu… - Biomedicine & …, 2019 - Elsevier
Heart failure (HF) leads to an increase in morbidity and mortality globally. Disorders of
energy metabolism and apoptosis of cardiomyocytes are critically involved in the …

The fucoidan from the brown seaweed Ascophyllum nodosum ameliorates atherosclerosis in apolipoprotein E-deficient mice

J Yin, J Wang, F Li, Z Yang, X Yang, W Sun, B Xia… - Food & function, 2019 - pubs.rsc.org
Hyperlipidemia is a major cause of atherosclerosis. Reverse cholesterol transport (RCT) is
believed to attenuate hyperlipidemia and the progression of atherosclerosis. Although …

MG53 Protects against Sepsis‐Induced Myocardial Dysfunction by Upregulating Peroxisome Proliferator‐Activated Receptor‐α

X Han, D Chen, N Liufu, F Ji, Q Zeng… - … Medicine and Cellular …, 2020 - Wiley Online Library
Background. The heart is one of the most commonly affected organs during sepsis.
Mitsugumin‐53 (MG53) has attracted attention in research due to its cardioprotective …

[HTML][HTML] Comparative hepatotoxicity of novel lithium bis (trifluoromethanesulfonyl) imide (LiTFSI, ie. HQ-115) and legacy Perfluorooctanoic acid (PFOA) in male mice …

M Sands, X Zhang, M Laws, M Spinella… - Environment …, 2024 - Elsevier
Abstract Lithium Bis (trifluoromethanesulfonyl) imide (LiTFSI ie. HQ-115), a polymer
electrolyte used in energy applications, has been detected in the environment, yet its health …

The fucoidan A3 from the seaweed Ascophyllum nodosum enhances RCT-related genes expression in hyperlipidemic C57BL/6J mice

Z Yang, J Yin, Y Wang, J Wang, B Xia, T Li… - International journal of …, 2019 - Elsevier
Reverse cholesterol transport (RCT) has been demonstrated to reduce hyperlipidemia, and
fucoidans are found to possess hypolipidemic effect. This study was designed to investigate …

ShenmaYizhi decoction improves the mitochondrial structure in the brain and ameliorates cognitive impairment in VCI rats via the AMPK/UCP2 signaling pathway

C Sun, M Liu, J Liu, T Zhang, L Zhang… - … Disease and Treatment, 2021 - Taylor & Francis
Background ShenmaYizhi decoction (SMYZD) is an effective prescription of traditional
Chinese medicine used to treat vascular dementia (VD). Modern research methods have …