Cardiac fibrosis: Myofibroblast-mediated pathological regulation and drug delivery strategies
Cardiac fibrosis remains an unresolved problem in heart diseases. After initial injury, cardiac
fibroblasts (CFs) are activated and subsequently differentiate into myofibroblasts (myoFbs) …
fibroblasts (CFs) are activated and subsequently differentiate into myofibroblasts (myoFbs) …
Peroxisome proliferator-activated receptors and their novel ligands as candidates for the treatment of non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) is a major health issue worldwide, frequently
associated with obesity and type 2 diabetes. Steatosis is the initial stage of the disease …
associated with obesity and type 2 diabetes. Steatosis is the initial stage of the disease …
Recent Insights on the Role of PPAR-β/δ in Neuroinflammation and Neurodegeneration, and Its Potential Target for Therapy
AK Strosznajder, S Wójtowicz, MJ Jeżyna… - Neuromolecular …, 2021 - Springer
Peroxisome proliferator-activated receptor (PPAR) β/δ belongs to the family of hormone and
lipid-activated nuclear receptors, which are involved in metabolism of long-chain fatty acids …
lipid-activated nuclear receptors, which are involved in metabolism of long-chain fatty acids …
Energy substrate metabolism and oxidative stress in metabolic cardiomyopathy
Metabolic cardiomyopathy is an emerging cause of heart failure in patients with obesity,
insulin resistance, and diabetes. It is characterized by impaired myocardial metabolic …
insulin resistance, and diabetes. It is characterized by impaired myocardial metabolic …
[HTML][HTML] Ginsenoside Rb3 regulates energy metabolism and apoptosis in cardiomyocytes via activating PPARα pathway
X Chen, Q Wang, M Shao, L Ma, D Guo, Y Wu… - Biomedicine & …, 2019 - Elsevier
Heart failure (HF) leads to an increase in morbidity and mortality globally. Disorders of
energy metabolism and apoptosis of cardiomyocytes are critically involved in the …
energy metabolism and apoptosis of cardiomyocytes are critically involved in the …
The fucoidan from the brown seaweed Ascophyllum nodosum ameliorates atherosclerosis in apolipoprotein E-deficient mice
J Yin, J Wang, F Li, Z Yang, X Yang, W Sun, B Xia… - Food & function, 2019 - pubs.rsc.org
Hyperlipidemia is a major cause of atherosclerosis. Reverse cholesterol transport (RCT) is
believed to attenuate hyperlipidemia and the progression of atherosclerosis. Although …
believed to attenuate hyperlipidemia and the progression of atherosclerosis. Although …
MG53 Protects against Sepsis‐Induced Myocardial Dysfunction by Upregulating Peroxisome Proliferator‐Activated Receptor‐α
X Han, D Chen, N Liufu, F Ji, Q Zeng… - … Medicine and Cellular …, 2020 - Wiley Online Library
Background. The heart is one of the most commonly affected organs during sepsis.
Mitsugumin‐53 (MG53) has attracted attention in research due to its cardioprotective …
Mitsugumin‐53 (MG53) has attracted attention in research due to its cardioprotective …
[HTML][HTML] Comparative hepatotoxicity of novel lithium bis (trifluoromethanesulfonyl) imide (LiTFSI, ie. HQ-115) and legacy Perfluorooctanoic acid (PFOA) in male mice …
M Sands, X Zhang, M Laws, M Spinella… - Environment …, 2024 - Elsevier
Abstract Lithium Bis (trifluoromethanesulfonyl) imide (LiTFSI ie. HQ-115), a polymer
electrolyte used in energy applications, has been detected in the environment, yet its health …
electrolyte used in energy applications, has been detected in the environment, yet its health …
The fucoidan A3 from the seaweed Ascophyllum nodosum enhances RCT-related genes expression in hyperlipidemic C57BL/6J mice
Z Yang, J Yin, Y Wang, J Wang, B Xia, T Li… - International journal of …, 2019 - Elsevier
Reverse cholesterol transport (RCT) has been demonstrated to reduce hyperlipidemia, and
fucoidans are found to possess hypolipidemic effect. This study was designed to investigate …
fucoidans are found to possess hypolipidemic effect. This study was designed to investigate …
ShenmaYizhi decoction improves the mitochondrial structure in the brain and ameliorates cognitive impairment in VCI rats via the AMPK/UCP2 signaling pathway
C Sun, M Liu, J Liu, T Zhang, L Zhang… - … Disease and Treatment, 2021 - Taylor & Francis
Background ShenmaYizhi decoction (SMYZD) is an effective prescription of traditional
Chinese medicine used to treat vascular dementia (VD). Modern research methods have …
Chinese medicine used to treat vascular dementia (VD). Modern research methods have …