Macrophages in atherosclerosis regression

TJ Barrett - Arteriosclerosis, thrombosis, and vascular biology, 2020 - Am Heart Assoc
Macrophages play a central role in the development of atherosclerotic cardiovascular
disease (ASCVD), which encompasses coronary artery disease, peripheral artery disease …

[PDF][PDF] Liver macrophages: old dogmas and new insights

A Guillot, F Tacke - Hepatology communications, 2019 - Wiley Online Library
Inflammation is a hallmark of virtually all liver diseases, such as liver cancer, fibrosis,
nonalcoholic steatohepatitis, alcoholic liver disease, and cholangiopathies. Liver …

TREM2 sustains macrophage-hepatocyte metabolic coordination in nonalcoholic fatty liver disease and sepsis

J Hou, J Zhang, P Cui, Y Zhou, C Liu… - The Journal of …, 2021 - Am Soc Clin Investig
Sepsis is a leading cause of death in critical illness, and its pathophysiology varies
depending on preexisting medical conditions. Here we identified nonalcoholic fatty liver …

Macrophage plasticity and atherosclerosis therapy

P Lin, HH Ji, YJ Li, SD Guo - Frontiers in molecular biosciences, 2021 - frontiersin.org
Atherosclerosis is a chronic disease starting with the entry of monocytes into the
subendothelium and the subsequent differentiation into macrophages. Macrophages are the …

Twin-bioengine self-adaptive micro/nanorobots using enzyme actuation and macrophage relay for gastrointestinal inflammation therapy

B Zhang, H Pan, Z Chen, T Yin, M Zheng, L Cai - Science Advances, 2023 - science.org
A wide array of biocompatible micro/nanorobots are designed for targeted drug delivery and
precision therapy largely depending on their self-adaptive ability overcoming complex …

Vascular macrophages in atherosclerosis

H Xu, J Jiang, W Chen, W Li… - Journal of immunology …, 2019 - Wiley Online Library
Atherosclerosis is the main pathological basis for the occurrence of most cardiovascular
diseases, the leading global health threat, and a great burden for society. It has been well …

Targeting of hepatic macrophages by therapeutic nanoparticles

CI Colino, JM Lanao, C Gutierrez-Millan - Frontiers in immunology, 2020 - frontiersin.org
Hepatic macrophage populations include different types of cells with plastic properties that
can differentiate into diverse phenotypes to modulate their properties in response to different …

Improvement of obesity-associated disorders by a small-molecule drug targeting mitochondria of adipose tissue macrophages

Y Wang, B Tang, L Long, P Luo, W Xiang, X Li… - Nature …, 2021 - nature.com
Pro-inflammatory activation of adipose tissue macrophages (ATMs) is causally linked to
obesity and obesity-associated disorders. A number of studies have demonstrated the …

Macrophage-based nanotherapeutic strategies in ulcerative colitis

J Zhang, Y Zhao, T Hou, H Zeng, D Kalambhe… - Journal of Controlled …, 2020 - Elsevier
Macrophages, an important component of the innate immune response, are a key regulator
of intestinal microenvironment homeostasis. These cells essentially contribute to chronic …

Macrophage-targeted nanomedicine for chronic diseases immunotherapy

Y Song, Y Huang, F Zhou, J Ding, W Zhou - Chinese Chemical Letters, 2022 - Elsevier
Macrophage is the key innate immune effector in first-line defense against the pathogens,
and can be polarized into different phenotypes to regulate a variety of immunological …