The prevalence of obesity and associated chronic diseases continues to increase
worldwide, negatively impacting on societies and economies. Whereas the association …

Adipose tissue is an endocrine organ and a crucial regulator of energy storage and systemic
metabolic homeostasis. Additionally, adipose tissue is a pivotal regulator of cardiovascular …

The risk associated with multiple cancers, cardiovascular disease, diabetes, and all-cause
mortality is decreased in individuals who meet the current recommendations for physical …

Adipose tissue exhibits a remarkable capacity to expand, contract, and remodel in response
to changes in physiological and environmental conditions. Here, we describe recent …

Adipocyte function is a major determinant of metabolic disease, warranting investigations of
regulating mechanisms. We show at single-cell resolution that progenitor cells from four …

Spatial transcriptomics (ST) methods unlock molecular mechanisms underlying tissue
development, homeostasis, or disease. However, there is a need for easy-to-use, high …

In obesity, sustained adipose tissue (AT) inflammation constitutes a cellular memory that
limits the effectiveness of weight loss interventions. Yet, the impact of fasting regimens on …

Obesity is associated with chronic, low-grade inflammation. Excessive nutrient intake causes
adipose tissue expansion, which may in turn cause cellular stress that triggers infiltration of …

Adipokines are biologically active factors secreted by adipose tissue that act on local and
distant tissues through autocrine, paracrine, and endocrine mechanisms. However …

In the healthy state, the fat stored in our body isn't just inert. Rather, it is dynamically
mobilized to maintain an adequate concentration of fatty acids (FAs) in our bloodstream. Our …