Immunotherapy discovery on tumor organoid-on-a-chip platforms that recapitulate the tumor microenvironment
Cancer immunotherapy has achieved remarkable success over the past decade by
modulating patients' own immune systems and unleashing pre-existing immunity. However …
modulating patients' own immune systems and unleashing pre-existing immunity. However …
[HTML][HTML] The functional role of extracellular matrix proteins in cancer
NV Popova, M Jücker - Cancers, 2022 - mdpi.com
Simple Summary Extracellular matrix is a three-dimensional network of macromolecules that
provide structural and biochemical support to surrounding cells. Extracellular matrix plays a …
provide structural and biochemical support to surrounding cells. Extracellular matrix plays a …
[HTML][HTML] Replacement, reduction, and refinement of animal experiments in anticancer drug development: The contribution of 3D in vitro cancer models in the drug …
In the last decades three-dimensional (3D) in vitro cancer models have been proposed as a
bridge between bidimensional (2D) cell cultures and in vivo animal models, the gold …
bridge between bidimensional (2D) cell cultures and in vivo animal models, the gold …
Circulating tumor cells in cancer diagnostics and prognostics by single-molecule and single-cell characterization
Circulating tumor cells (CTCs) represent an interesting source of biomarkers for diagnosis,
prognosis, and the prediction of cancer recurrence, yet while they are extensively studied in …
prognosis, and the prediction of cancer recurrence, yet while they are extensively studied in …
[HTML][HTML] The variety of 3D breast cancer models for the study of tumor physiology and drug screening
E Fröhlich - International Journal of Molecular Sciences, 2023 - mdpi.com
Breast cancer is the most common cancer in women and responsible for multiple deaths
worldwide. 3D cancer models enable a better representation of tumor physiology than the …
worldwide. 3D cancer models enable a better representation of tumor physiology than the …
[HTML][HTML] The multi-dimensional biomarker landscape in cancer immunotherapy
The field of immuno-oncology is now at the forefront of cancer care and is rapidly evolving.
The immune checkpoint blockade has been demonstrated to restore antitumor responses in …
The immune checkpoint blockade has been demonstrated to restore antitumor responses in …
[HTML][HTML] An optimized workflow for the analysis of metabolic fluxes in cancer spheroids using Seahorse technology
Three-dimensional cancer models, such as spheroids, are increasingly being used to study
cancer metabolism because they can better recapitulate the molecular and physiological …
cancer metabolism because they can better recapitulate the molecular and physiological …
Molecular insights of metastasis and cancer progression derived using 3D cancer spheroid co-culture in vitro platform
The multistep metastasis process is carried out by the combinatorial effect of the stromal
cells and the cancerous cells and plays vital role in the cancer progression. The …
cells and the cancerous cells and plays vital role in the cancer progression. The …
[HTML][HTML] Atlas of lobular breast cancer models: challenges and strategic directions
Simple Summary Invasive lobular breast cancer (ILC) is the second most common
histological subtype of invasive breast cancer, which is noted to have a unique microscopic …
histological subtype of invasive breast cancer, which is noted to have a unique microscopic …
Osteosarcoma tumor microenvironment: the key for the successful development of biologically relevant 3D in vitro models
Osteosarcoma (OS) is the most common primary bone cancer in children and young adults.
This type of cancer is characterized by a high mortality rate, especially for patients with …
This type of cancer is characterized by a high mortality rate, especially for patients with …