Post-translational modifications (PTMs) are ubiquitous and key to regulating protein function.
Understanding the dynamics of individual PTMs and their biological roles requires robust …

The rapid development of metabolomics has significantly advanced health and disease
related research. However, metabolite identification remains a major analytical challenge for …

Neuropeptides are important mediators in the functionality of the brain and other
neurological organs. Because neuropeptides exist in a wide range of concentrations …

Fucose migration reactions represent a substantial challenge in the analysis of fucosylated
glycan structures by mass spectrometry. In addition to the well-established observation of …

Stereochemical modifications (SCMs), mostly present in the form of d-amino acid
substitution, have been increasingly identified from a wide range of neuropeptides and …

Ion mobility-mass spectrometry (IM-MS) has emerged as a highly important analytical
technique for the structural elucidation of a wide range of biomolecules, including …

The present review covers available results on the application of FT‐MS for the de novo
sequencing of natural peptides of various animals: cones, bees, snakes, amphibians …

Isomers are compounds with the same molecular formula. Many different types of isomers
are ubiquitous and play important roles in living organisms. Despite their early discovery, the …

Protein sequencing by mass spectrometry has transformed the field of biopharmaceutical
analysis, but a missing part in the analytical toolkit is the ability to distinguish between the …

The discovery of insulin in the early 1900s ushered in the era of research related to peptides
acting as hormones and neuromodulators, among other regulatory roles. These essential …