A guide to complement biology, pathology and therapeutic opportunity
DC Mastellos, G Hajishengallis… - Nature Reviews …, 2024 - nature.com
Complement has long been considered a key innate immune effector system that mediates
host defence and tissue homeostasis. Yet, growing evidence has illuminated a broader …
host defence and tissue homeostasis. Yet, growing evidence has illuminated a broader …
Glomerulonephritis: immunopathogenesis and immunotherapy
Abstract 'Glomerulonephritis'(GN) is a term used to describe a group of heterogeneous
immune-mediated disorders characterized by inflammation of the filtration units of the kidney …
immune-mediated disorders characterized by inflammation of the filtration units of the kidney …
KDIGO 2021 clinical practice guideline for the management of glomerular diseases
BH Rovin, SG Adler, J Barratt, F Bridoux… - Kidney …, 2021 - kidney-international.org
Glomerular disease, be it primary or secondary, occurring in the setting of systemic
autoimmune diseases, infections, drugs, or malignancy, affects individuals of all ages. In …
autoimmune diseases, infections, drugs, or malignancy, affects individuals of all ages. In …
Innate immunity in diabetic kidney disease
SCW Tang, WH Yiu - Nature Reviews Nephrology, 2020 - nature.com
Increasing evidence suggests that renal inflammation contributes to the pathogenesis and
progression of diabetic kidney disease (DKD) and that anti-inflammatory therapies might …
progression of diabetic kidney disease (DKD) and that anti-inflammatory therapies might …
Crosstalk between the renin–angiotensin, complement and kallikrein–kinin systems in inflammation
Z Bekassy, I Lopatko Fagerström, M Bader… - Nature Reviews …, 2022 - nature.com
During severe inflammatory and infectious diseases, various mediators modulate the
equilibrium of vascular tone, inflammation, coagulation and thrombosis. This Review …
equilibrium of vascular tone, inflammation, coagulation and thrombosis. This Review …
Clinical promise of next-generation complement therapeutics
The complement system plays a key role in pathogen immunosurveillance and tissue
homeostasis. However, subversion of its tight regulatory control can fuel a vicious cycle of …
homeostasis. However, subversion of its tight regulatory control can fuel a vicious cycle of …
Genetic testing in the diagnosis of chronic kidney disease: recommendations for clinical practice
N Knoers, C Antignac, C Bergmann… - Nephrology Dialysis …, 2022 - academic.oup.com
The overall diagnostic yield of massively parallel sequencing–based tests in patients with
chronic kidney disease (CKD) is 30% for paediatric cases and 6–30% for adult cases. These …
chronic kidney disease (CKD) is 30% for paediatric cases and 6–30% for adult cases. These …
[HTML][HTML] A systematic review of immune checkpoint inhibitor–associated glomerular disease
A Kitchlu, KD Jhaveri, S Wadhwani… - Kidney international …, 2021 - Elsevier
Introduction Immune checkpoint inhibitors (ICIs) are increasingly used to treat cancers.
Kidney immune-related adverse events (IRAEs) are now well recognized, with the incidence …
Kidney immune-related adverse events (IRAEs) are now well recognized, with the incidence …
Epidemiology, pathogenesis, treatment and outcomes of infection-associated glomerulonephritis
AA Satoskar, SV Parikh, T Nadasdy - Nature Reviews Nephrology, 2020 - nature.com
For over a century, acute 'post-streptococcal glomerulonephritis'(APSGN) was the
prototypical form of bacterial infection-associated glomerulonephritis, typically occurring …
prototypical form of bacterial infection-associated glomerulonephritis, typically occurring …
Complement factor D as a strategic target for regulating the alternative complement pathway
J Barratt, I Weitz - Frontiers in immunology, 2021 - frontiersin.org
The complement system is central to first-line defense against invading pathogens.
However, excessive complement activation and/or the loss of complement regulation …
However, excessive complement activation and/or the loss of complement regulation …