Background The pathophysiology of the leading cause of pediatric acute nephritis, acute
postinfectious GN, including mechanisms of the pathognomonic transient complement …

Introduction The association between a change in proteinuria over time and its impact on
kidney prognosis has not been analysed in complement component 3 (C3) glomerulopathy …

Kidney glomerulosclerosis commonly progresses to end-stage kidney failure, but
pathogenic mechanisms are still poorly understood. Here, we show that podocyte …

The complement system comprises the frontline of the innate immune system. Triggered by
pathogenic surface patterns in different pathways, the cascade concludes with the formation …

Introduction Complement 3 glomerulopathy (C3G) is a rare inflammatory kidney disease
mediated by dysregulation of the alternative complement pathway. No targeted therapy …

In April 2012, a group of nephrologists organized a consensus conference in Cambridge
(UK) on type II membranoproliferative glomerulonephritis and decided to use a new …

Introduction Dysregulated complement activation is likely the primary driver of disease in C3
glomerulopathy (C3G) and contributes to other complement-mediated diseases, including …

Inflammation is a common denominator of diseases. The complement system, an intrinsic
part of the innate immune system, is a key driver of inflammation in numerous disorders …

C3 glomerulopathy (C3G) is a rare complement-mediated disease. Specific treatments are
not yet available and factors predictive of kidney survival such as age, kidney function and …

In 2007 and 2009, the regulatory approval of the first-in-class complement inhibitor
eculizumab revolutionized the clinical management of 2 rare, life-threatening clinical …