Recently, the comprehensive concept of “infection-related glomerulonephritis (IRGN)” has
replaced that of postinfectious glomerulonephritis (PIGN) because of the diverse infection …

Complement is an evolutionarily conserved system which is important in the defense against
microorganisms and also in the elimination of modified or necrotic elements of the body …

Complement factor I (FI) is the nexus for classical, lectin and alternative pathway
complement regulation. FI is an 88kDa plasma protein that circulates in an inactive …

Uncontrolled alternative pathway activation is the primary driver of several diseases, and it
contributes to the pathogenesis of many others. Consequently, diagnostic tests to monitor …

The complement pathway is an essential mechanism in innate immunity, but it is also
involved in multiple pathologies. For kidney diseases, strong evidence of a dysregulation in …

The ancient origin of the lectin pathway of the complement system can be traced back to
protochordates (such as amphioxus and tunicates) by the presence of components such as …

Mass spectrometry-based assays have been increasingly implemented in various
disciplines in clinical diagnostic laboratories for their combined advantages in multiplexing …

Rationale & Objective C3 glomerulopathy (C3GN) and atypical hemolytic uremic syndrome
(aHUS) are 2 distinct rare kidney diseases caused by dysregulation of the alternative …

Complement plays an essential role in the opsonophagocytic clearance of apoptotic/necrotic
cells. Dysregulation of this process may lead to inflammatory and autoimmune diseases …

Complement-mediated inflammation or dysregulation in lipid metabolism are associated
with the pathogenesis of several diseases. These include age-related macular degeneration …