Demographic, clinical characteristics and treatment outcomes of immune-complex membranoproliferative glomerulonephritis and C3 glomerulonephritis in Japan: A …
N Nakagawa, M Mizuno, S Kato, S Maruyama, H Sato… - PLoS …, 2021 - journals.plos.org
The reclassification of membranoproliferative glomerulonephritis (MPGN) into immune-
complex MPGN (IC-MPGN) and C3 glomerulopathy (C3G) based on immunofluorescence …
complex MPGN (IC-MPGN) and C3 glomerulopathy (C3G) based on immunofluorescence …
The complement system in pediatric acute kidney injury
EK Stenson, J Kendrick, B Dixon, JM Thurman - Pediatric Nephrology, 2023 - Springer
The complement cascade is an important part of the innate immune system. In addition to
helping the body to eliminate pathogens, however, complement activation also contributes …
helping the body to eliminate pathogens, however, complement activation also contributes …
Factor D inhibition blocks complement activation induced by mutant factor B associated with atypical hemolytic uremic syndrome and membranoproliferative …
SS Aradottir, AC Kristoffersson, LT Roumenina… - Frontiers in …, 2021 - frontiersin.org
Complement factor B (FB) mutant variants are associated with excessive complement
activation in kidney diseases such as atypical hemolytic uremic syndrome (aHUS), C3 …
activation in kidney diseases such as atypical hemolytic uremic syndrome (aHUS), C3 …
[HTML][HTML] Complement factor I: Regulatory nexus, driver of immunopathology, and therapeutic
TM Hallam, SJ Sharp, A Andreadi, D Kavanagh - Immunobiology, 2023 - Elsevier
Complement factor I (FI) is the nexus for classical, lectin and alternative pathway
complement regulation. FI is an 88kDa plasma protein that circulates in an inactive …
complement regulation. FI is an 88kDa plasma protein that circulates in an inactive …
Increased renal expression of complement components in patients with liver diseases: nonalcoholic steatohepatitis, alcohol-associated, viral hepatitis, and alcohol …
KL Frost, JL Jilek, AD Thompson, RR Klein… - Toxicological …, 2022 - academic.oup.com
Inflammatory liver diseases, including nonalcoholic steatohepatitis (NASH), alcohol-
associated liver disease (ALD), hepatitis C virus (HCV), and ALD/HCV, account for nearly 2 …
associated liver disease (ALD), hepatitis C virus (HCV), and ALD/HCV, account for nearly 2 …
The evolving role of novel biomarkers in glomerular disease: a review
C Cavanaugh, MD Okusa - American Journal of Kidney Diseases, 2021 - Elsevier
Recent advances in glomerular biology have expanded our understanding of glomerular
diseases, leading to more precise therapeutic options. Since the discovery of the …
diseases, leading to more precise therapeutic options. Since the discovery of the …
Recurrent C3 glomerulopathy after kidney transplantation
The complement system is part of innate immunity and is pivotal in protecting the body
against pathogens and maintaining host homeostasis. Activation of the complement system …
against pathogens and maintaining host homeostasis. Activation of the complement system …
Complement C3-targeted therapy in C3 glomerulopathy, a prototype of complement-mediated kidney diseases
MS Meuleman, A Grunenwald, S Chauvet - Seminars in Immunology, 2022 - Elsevier
Abstract C3 glomerulopathy (C3G) is a rare and complex kidney disease that primarily
affects young adults. Renal outcomes remain poor in the absence of specific treatment. C3G …
affects young adults. Renal outcomes remain poor in the absence of specific treatment. C3G …
Therapy and outcomes of C3 glomerulopathy and immune-complex membranoproliferative glomerulonephritis
P Khandelwal, S Bhardwaj, G Singh, A Sinha… - Pediatric …, 2021 - Springer
Background Data on therapy and outcome of dense deposit disease (DDD), C3
glomerulonephritis (C3GN), and immune-complex MPGN (IC-MPGN) in children are limited …
glomerulonephritis (C3GN), and immune-complex MPGN (IC-MPGN) in children are limited …
Improving clinical trials for anticomplement therapies in complement-mediated glomerulopathies: report of a scientific workshop sponsored by the National Kidney …
AS Bomback, GB Appel, DS Gipson… - American Journal of …, 2022 - Elsevier
Blocking the complement system as a therapeutic strategy has been proposed for numerous
glomerular diseases but presents myriad questions and challenges, not the least of which is …
glomerular diseases but presents myriad questions and challenges, not the least of which is …