Autoimmune kidney diseases occur due to the loss of tolerance to self-antigens, resulting in
inflammation and pathological damage to the kidneys. This review focuses on the known …

Background Data on therapy and outcome of dense deposit disease (DDD), C3
glomerulonephritis (C3GN), and immune-complex MPGN (IC-MPGN) in children are limited …

C5b-9 plays an important role in the pathogenesis of immunoglobin A nephropathy (IgAN).
We evaluated C5b-9 as a prognostic marker for IgAN. We prospectively enrolled 33 patients …

Introduction: Periodontal Ehlers-Danlos Syndrome (pEDS) is a rare autosomal dominant
type of EDS characterised by severe early-onset periodontitis, lack of attached gingiva …

Background Genetic variants in complement genes have been associated with a wide range
of human disease states, but well-powered genetic association studies of complement …

The kidney is comprised of highly complex structures that rely on self-maintenance for their
functions, and tissue repair and regeneration in renal diseases. We devised a proteomics …

C3 glomerulopathy is a relatively new clinical entity that represents a challenge both to
diagnose and to treat. As new therapeutic agents that act as complement inhibitors become …

Alternative pathway complement dysregulation with abnormal glomerular C3 deposits and
glomerular damage is a key mechanism of pathology in C3 glomerulopathy (C3G). No …

Hematuria and proteinuria are among the common reason why children are referred to a
pediatric nephrologist. The initial step in a child with hematuria is to establish the diagnosis …

Background IgG and complement 3 (C3) are generally found to be deposited along the
glomerular basement membrane (GBM) in human anti-GBM disease. The pathogenic role of …