C3 glomerulopathy is a relatively new clinical entity that represents a challenge both to
diagnose and to treat. As new therapeutic agents that act as complement inhibitors become …

Background IgG and complement 3 (C3) are generally found to be deposited along the
glomerular basement membrane (GBM) in human anti-GBM disease. The pathogenic role of …

Therapeutic monoclonal antibodies (MAbs) have been one of the fastest growing drug
classes in the past 2 decades and are indicated in the treatment of cancer, autoimmune …

This chapter discusses the pathogenesis of autoimmune diseases that affect the kidneys.
The human immune system has the ability to distinguish self and nonself antigens via a …

The complement system is an ancient and phylogenetically conserved key danger sensing
system that is critical for host defense against pathogens. Activation of the complement …

The complement system, an important part of the innate system, is known to play a central
role in many immune mediated kidney diseases. All parts of the complement system …

C5b-9 plays an important role in the pathogenesis of immunoglobin A nephropathy (IgAN).
We evaluated C5b-9 as a prognostic marker for IgAN. We prospectively enrolled 33 patients …

“Autoinflammatory disease (AiD)” has first been introduced in 1999 when the responsible
gene for the familial Hibernean fever or autosomal dominant-type familial Mediterranean …

The rare and heterogeneous kidney disorder C3 glomerulopathy (C3G) is characterized by
dysregulation of the alternative pathway (AP) of the complement system. C3G is often …

Acute kidney injury associated with glomerular diseases : Current Opinion in Critical Care
Acute kidney injury associated with glomerular diseases : Current Opinion in Critical Care Log …