Many patients with chest pain undergoing coronary angiography do not show significant
obstructive coronary lesions. A substantial proportion of these patients have abnormalities in …

Inflammation is increasingly implicated as a risk factor for dementia, stroke, and small vessel
disease (SVD). However, the underlying mechanisms and causative pathways remain …

Few studies have focused on the connection between glymphatic dysfunction and cerebral
small vessel disease (CSVD), partially due to the lack of non-invasive methods to measure …

Two previous pan-European consensus meetings, the 1995 and 2006 Helsingborg
meetings, were convened to review the scientific evidence and the state of current services …

Importance Racial and ethnic groups with higher rates of clinical Alzheimer disease (AD) are
underrepresented in studies of AD biomarkers, including amyloid positron emission …

Objective To examine the association between systemic inflammation measured during
midlife and 20-year cognitive decline. Methods Within the Atherosclerosis Risk in …

Context Chronic obesity is associated with several complications, including cognitive
impairment and dementia. However, we have only piecemeal knowledge of the mechanisms …

Cerebral small vessel disease (cSVD) is the most common cause of vascular cognitive
impairment and affects all levels of the brain's vasculature. Features include diverse …

Background: Mechanisms underlying the association between age-related arterial stiffening
and poor brain health remain elusive. Cerebral blood flow (CBF) homeostasis may be …

Importance Neuroimaging studies have documented racial and ethnic disparities in brain
health in old age. It remains unclear whether these disparities are apparent in midlife …