Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …

A new coronavirus (CoV) caused a pandemic named COVID-19, which has become a
global health care emergency in the present time. The virus is referred to as SARS-CoV-2 …

Conspectus Alzheimer's disease (AD), as the primary cause of dementia, has seriously
affected millions of people worldwide and brought a very heavy financial and social burden …

Type 2 diabetes mellitus is a progressive disease that is characterized by the appearance of
insulin resistance. The term insulin resistance is very wide and could affect different proteins …

Amyloid self-assembly is linked to numerous devastating cell-degenerative diseases.
However, designing inhibitors of this pathogenic process remains a major challenge. Cross …

Diabetes affects hundreds of millions of patients worldwide. Despite the advances in
understanding the disease and therapeutic options, it remains a leading cause of death and …

Functional amyloid is produced by many organisms but is particularly well understood in
bacteria, where proteins such as CsgA (E. coli) and FapC (Pseudomonas) are assembled as …

Fibrillary aggregates of amyloid-β (Aβ) are the pathological hallmark of Alzheimer's disease
(AD). Clearing Aβ deposition or inhibiting Aβ aggregation is a promising approach to treat …

The aggregation of misfolded tau into neurotoxic fibrils is linked to the progression of
Alzheimer's disease (AD) and related tauopathies. Disease-associated conformations of …

Host-defense peptides have drawn significant attention as new drugs or drug adjuvants to
combat multidrug-resistant bacteria. In this study, we report the development of cyclic …