As crucial antigen presenting cells, dendritic cells (DCs) play a vital role in tumor
immunotherapy. Taking into account the many recent advances in DC biology, we discuss …

Lipopolysaccharide (LPS) is a crucial constituent of the outer membrane of most Gram-
negative bacteria, playing a fundamental role in the protection of bacteria from …

The C-type lectins are a superfamily of proteins that recognize a broad repertoire of ligands
and that regulate a diverse range of physiological functions. Most research attention has …

Early weaning usually causes intestinal disorders, enteritis, and diarrhea in young animals
and human infants. Astragalus polysaccharides (APS) possesses anti‐inflammatory activity …

Highlights•Sugar-binding C-type carbohydrate-recognition domains fall in five structural
groups.•Structures for many of these domains, covering all of the groups, have been …

Pathogen recognition by C-type lectin receptors (CLRs) expressed by dendritic cells is
important not only for antigen presentation, but also for the induction of appropriate adaptive …

Polyubiquitination of proteins has a pivotal role in the regulation of numerous cellular
functions such as protein degradation, DNA repair and cell signaling. As deregulation of …

C-type lectin receptors (CLRs) are important pattern recognition receptors involved in
recognition and induction of adaptive immunity to pathogens. Certain CLRs play an …

One of the key features of the immune system is its extraordinary capacity to discriminate
between self and non-self and to respond accordingly. Several molecular interactions allow …

Aberrant glycosylation of tumor cells is recognized as a universal hallmark of cancer
pathogenesis. Overexpression of fucosylated epitopes, such as type I (H1, Lewisa, Lewisb …