Impulsivity and compulsivity represent useful conceptualizations that involve dissociable
cognitive functions, which are mediated by neuroanatomically and neurochemically distinct …

Impulsivity critically relates to many psychiatric disorders. Given the multifaceted construct
that impulsivity represents, defining core aspects of impulsivity is vital for the assessment …

The factors causing the transition from recreational drug consumption to addiction remain
largely unknown. It has not been tested whether dopamine (DA) is sufficient to trigger this …

Substance use and abuse begin during adolescence. Male and female adolescent humans
initiate use at comparable rates, but males increase use faster. In adulthood, more men than …

Maladaptive impulsivity is a core symptom in various psychiatric disorders. However, there is
only limited evidence available on whether different measures of impulsivity represent …

Behavioral tendencies that might be captured through self-report measures may provide
insight into personality features that are associated with substance addictions. Recently …

Some rats [sign-trackers (STs)] are especially prone to attribute incentive salience to reward
cues, relative to others [goal-trackers (GTs)]. Thus, reward cues are more likely to promote …

The interaction of drugs with biologic targets is a critical area of research, particularly for the
development of medications to treat substance use disorders. In addition to understanding …

Poor decision making and elevated risk taking, particularly during adolescence, have been
strongly linked to drug use; however the causal relationships among these factors are not …

Compulsive drug use and a persistent vulnerability to relapse are key features of addiction.
Imaging studies have suggested that these features may result from deficits in prefrontal …