The endoplasmic reticulum (ER) is a membranous intracellular organelle and the first
compartment of the secretory pathway. As such, the ER contributes to the production and …

Cancer cells encounter numerous stresses that pose a threat to their survival. Tumor
microenviroment stresses that perturb protein homeostasis can produce endoplasmic …

The unfolded protein response (UPR) is a conserved pathway that is stimulated when
endoplasmic reticulum (ER) proteostasis is disturbed or lost. Accumulating evidence …

Nonsense-mediated mRNA decay (NMD) is a conserved mRNA surveillance pathway that
cells use to ensure the quality of transcripts and to fine-tune transcript abundance. The role …

Tumors undergo fast neovascularization to support the rapid proliferation of cancer cells.
Vasculature in tumors, unlike that in wound healing, is immature and affects the tumor …

Nonsense-mediated decay (NMD) was first described as a quality-control mechanism that
targets and rapidly degrades aberrant mRNAs carrying premature termination codons …

Tumor-associated macrophages (TAMs) represent the M2-like phenotype with potent
immunosuppressive activity, and play a pro-tumor role in pancreatic ductal adenocarcinoma …

Melanomas are tumors originating from melanocytes and tend to show early metastasis
secondary to the loss of cellular adhesion in the primary tumor, resulting in high mortality …

Prostate cancer (PCa) is primarily driven by aberrant Androgen Receptor (AR) signaling.
Although there has been substantial advancement in antiandrogen therapies, resistance to …

Endoplasmic reticulum (ER) stress disrupts among others protein homeostasis in cells
leading to the activation of the unfolded protein response (UPR) that is crucial for restoring …