Circulating non-coding RNAs in chronic kidney disease and its complications

AJ van Zonneveld, Q Zhao, JI Rotmans… - Nature Reviews …, 2023 - nature.com
Post-transcriptional regulation by non-coding RNAs (ncRNAs) can modulate the expression
of genes involved in kidney physiology and disease. A large variety of ncRNA species exist …

Mesenchymal stem cell therapy in kidney diseases: potential and challenges

F Chen, NN Chen, C Xia, H Wang, L Shao… - Cell …, 2023 - journals.sagepub.com
Kidney disease (KD) is a life-threatening disease characterized by high morbidity and
mortality in clinical settings, which can be caused by many reasons, and the incidence …

Synergistic vesicle-vector systems for targeted delivery

CA Marquez, CI Oh, G Ahn, WR Shin, YH Kim… - Journal of …, 2024 - Springer
With the immense progress in drug delivery systems (DDS) and the rise of nanotechnology,
challenges such as target specificity remain. The vesicle-vector system (VVS) is a delivery …

Exploring the therapeutic significance of microRNAs and lncRNAs in kidney diseases

LA Bravo-Vázquez, S Paul, MG Colín-Jurado… - Genes, 2024 - mdpi.com
MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are two crucial classes of
transcripts that belong to the major group of non-coding RNAs (ncRNAs). These RNA …

The multifaceted roles of small extracellular vesicles in metabolic reprogramming in the tumor microenvironments

Z Chen, JWP Yam, X Mao - Proteomics, 2024 - Wiley Online Library
The link between metabolism and tumor progression has been extensively researched for a
long time. With the increasing number of studies uncovering the multiple functions of …

[HTML][HTML] BMSCs-derived exosomes inhibit macrophage/microglia pyroptosis by increasing autophagy through the miR-21a-5p/PELI1 axis in spinal cord injury

J Gu, J Wu, C Wang, Z Xu, Z Jin, D Yan… - Aging (Albany NY …, 2024 - ncbi.nlm.nih.gov
Spinal cord injury (SCI) results in a diverse range of disabilities and lacks effective treatment
options. In recent years, exosomes derived from bone mesenchymal stem cells (BMSCs) …

Glycolytic reprogramming in organ fibrosis: New dynamics of the epigenetic landscape

ZY Liu, K Song, B Tu, LC Lin, H Sun, Y Zhou… - Free Radical Biology …, 2023 - Elsevier
Accumulating evidence has shown that aerobic glycolysis is essential for the establishment
and maintenance of the fibrotic phenotype, so treatments targeting glycolytic reprogramming …

Extracellular vesicles in chronic kidney disease: diagnostic and therapeutic roles

Y Zheng, H Wang, X Li, J Xie, J Fan… - Frontiers in …, 2024 - frontiersin.org
Chronic kidney disease (CKD) is a progressive disorder characterized by structural and
functional changes in the kidneys, providing a global health challenge with significant …

[PDF][PDF] 急性肾损伤诊断的早期标志物的研究进展

韩云彪, 赵奕雯, 徐丽斌 - 中国医药导报, 2023 - yiyaodaobao.com.cn
急性肾损伤(AKI) 是肾内科急危重症, 虽然绝大多数医师己经提高了对AKI 的认识,
但目前仍有较高的漏诊率及死亡率, 部分患者可慢性化改变, 以肌肝及尿量作为主要诊断指标单ñ …

Exosomes From Human Umbilical Cord Stem Cells Suppress Macrophage-to-myofibroblast Transition, Alleviating Renal Fibrosis

Q Guo, P Li, M Chen, Y Yu, Y Wan, Z Zhang, C Ren… - Inflammation, 2024 - Springer
Renal fibrosis, a progressive scarring of the kidney, lacks effective treatment. Human
umbilical cord mesenchymal stem cell-derived exosomes (HucMSC-Exos) hold promise for …