Kidney fibrosis, characterized by excessive deposition of extracellular matrix (ECM) that
leads to tissue scarring, is the final common outcome of a wide variety of chronic kidney …

Chronic kidney disease (CKD) is a chronic renal dysfunction syndrome that is characterized
by nephron loss, inflammation, myofibroblasts activation, and extracellular matrix (ECM) …

Extracellular vesicles (EVs), a cluster of cell-secreted lipid bilayer nanoscale particles,
universally exist in body fluids, as well as cell and tissue culture supernatants. Over the past …

Background and aims Nephrolithiasis is a common renal disease with no effective
medication. Sodium-glucose cotransporter-2 (SGLT2) inhibitors, an anti-diabetic agent, have …

Ionizing radiation (IR) is associated with the occurrence of enteritis, and protecting the whole
intestine from radiation-induced gut injury remains an unmet clinical need. Circulating …

Renal interstitial fibrosis is the common pathological process of various chronic kidney
diseases to end-stage renal disease. Inhibition of fibroblast activation attenuates renal …

Background Since angiogenesis occurs as the pathological process following myocardial
infarction to alleviate ischemia, therapeutic angiogenesis has been proposed to be a …

Extracellular vesicles (EVs), membranous vesicles present in all body fluids, are considered
important messengers, carrying their information over long distance and modulating the …

Fibrosis is a pathological condition characterized by the excessive deposition of
extracellular matrix components in tissues and organs, leading to progressive architectural …

The increasing prevalence of chronic kidney disease (CKD) is a major global public health
concern. Despite the complicated pathogenesis of CKD, renal fibrosis represents the most …