The glomerular filtration barrier is composed of glomerular endothelial cells, the glomerulus
basement membrane and the podocyte cell layer. The filtration barrier is a target of injury in …

Injury to the podocytes is the initiating cause of many renal diseases, leading to proteinuria
with possible progression to end-stage renal disease. Podocytes are highly specialized …

In recent years there has been an explosion of interest in the glomerular podocyte, which
plays a central role in control of glomerular filtration. A host of new molecules have been …

Proteinuric kidney diseases are a group of disorders with diverse pathological mechanisms
associated with significant losses of protein in the urine. The glomerular filtration barrier …

Micro-RNAs (miRNAs) are short (average 22 nucleotides) noncoding regulatory RNAs that
inhibit gene expression by targeting complementary 3′-untranslated regions of protein …

Podocytes are specialized epithelial cells of the kidney blood filtration barrier that contribute
to permselectivity via a series of interdigitating actin–rich foot processes. Positioned …

Minimal change disease (MCD) is the most common type of idiopathic nephrotic syndrome
in childhood and represents about 15% cases in adults. It is characterized by massive …

Objective Obesity‐related glomerulopathy is characterized initially by glomerular
hyperfiltration with hypertrophy and then development of proteinuria. Putative mechanisms …

Src homology 2 (SH2) domains mediate selective protein–protein interactions with tyrosine
phosphorylated proteins, and in doing so define specificity of phosphotyrosine (pTyr) …

PLCE1 encodes phospholipase C epsilon, and its mutations cause recessive nephrotic
syndrome. However, the mechanisms by which PLCE1 mutations result in defects …