The key intrinsic cell of the glomerulus is the podocyte, which is described as the “organiser
and caretaker” of glomerular structure and function (Leeuwis et al., 2010). Podocytes (also …

The function of the kidney, filtering blood and concentrating metabolic waste into urine, takes
place in an intricate and functionally elegant structure called the renal glomerulus. Normal …

Receptor ROBO2 and its ligand SLIT2 are required for ureteric bud outgrowth during early
kidney development. However, it is unclear if ROBO2 also plays a role during the late stage …

Proteinuria is highly relevant in nephropathies. A common cause for proteinuria is the
damage of the glomerular filter. Podocytes are part of the glomerular filter and the slit …

Background. Diabetes mellitus is a metabolic disease characterised by the inability of the
body to maintain stable glycaemia. Diabetic kidney disease (DKD), the renal complication of …

Albuminuria is an early clinical marker of a glomerular filter defect in hypertensive and
diabetic nephropathy and correlates with cardiovascular risk. The albuminuria results from a …

Endocytic trafficking couples cell signaling with the cytoskeletal dynamics by organizing a
crosstalk between protein networks in different subcellular compartments. Proteins residing …

Kidney podocytes maintain blood filtration selectivity through a network of actin-based
projections termed foot processes. The slit diaphragm is a molecular barrier that lies laterally …

Nephrotic syndrome is clinically characterized by massive proteinuria, and
hypoalbuminemia. It represents a heterogeneous group of glomerular disorders …