Melatonin is a pleotropic molecule with numerous biological activities. Epidemiological and
experimental studies have documented that melatonin could inhibit different types of cancer …

Ovarian cancer is the seventh most common gynaecologic malignancy seen in women.
Majority of the patients with ovarian cancer are diagnosed at the advanced stage making …

Background Rucaparib, a poly (ADP-ribose) polymerase inhibitor, has anticancer activity in
recurrent ovarian carcinoma harbouring a BRCA mutation or high percentage of genome …

We present an exceptional case of a patient with high-grade serous ovarian cancer, treated
with multiple chemotherapy regimens, who exhibited regression of some metastatic lesions …

Approximately 50% of epithelial ovarian cancers (EOC) exhibit defective DNA repair via
homologous recombination (HR) due to genetic and epigenetic alterations of HR pathway …

Inflammatory cytokines are highly inducible small glycoproteins or regulatory proteins of low
molecular weight secreted by different cell types. They regulate intercellular communication …

Ovarian cancer is the fifth-leading cause of cancer-related death in women. The strongest
known risk factors are familial genetic syndromes, such as BRCA gene mutations and …

High-grade serous ovarian cancer, also known as high-grade serous carcinoma (HGSC), is
the most common and deadliest type of ovarian cancer. HGSC appears to arise from the …

Objectives: Describe the epidemiology of ovarian cancer. Review the evaluation of a patient
with suspected ovarian cancer. Summarize the treatment options of ovarian cancer. Outline …

Purpose The frequency of BRCA1 and BRCA2 germ-line mutations in women with ovarian
cancer is unclear; reports vary from 3% to 27%. The impact of germ-line mutation on …