Molecular targets of gemcitabine action: rationale for development of novel drugs and drug combinations
M Elnaggar, E Giovannetti… - Current pharmaceutical …, 2012 - ingentaconnect.com
Gemcitabine is one of the most widely used pyrimidine analogues, with a well-established
role as a first-and second-line treatment of several types of tumors. Several preclinical and …
role as a first-and second-line treatment of several types of tumors. Several preclinical and …
The role of apoptosis in 2′, 2′-difluoro-2′-deoxycytidine (gemcitabine)-mediated radiosensitization
TS Lawrence, MA Davis, A Hough, A Rehemtulla - Clinical cancer research, 2001 - AACR
Abstract The nucleoside analogue Gemcitabine [2′, 2′-difluoro-2′-deoxycytidine
(dFdCyd)] is active against a wide variety of solid tumors and is a potent radiation sensitizer …
(dFdCyd)] is active against a wide variety of solid tumors and is a potent radiation sensitizer …
Cell cycle arrest and apoptosis in TP53 subtypes of bladder carcinoma cell lines treated with cisplatin and gemcitabine
GN da Silva, JP de Castro Marcondes… - Experimental …, 2010 - journals.sagepub.com
Currently, the combination of cisplatin and gemcitabine is considered a standard
chemotherapeutic protocol for bladder cancer. However, the mechanism by which these …
chemotherapeutic protocol for bladder cancer. However, the mechanism by which these …
Induction of cyclin E and inhibition of DNA synthesis by the novel acronycine derivative S23906-1 precede the irreversible arrest of tumor cells in S phase leading to …
S Léonce, V Pérez, S Lambel, D Peyroulan… - Molecular …, 2001 - ASPET
S23906-1 is a diester derivative of 1, 2-dihydrobenzo [b] acronycine with an unknown
mechanism of action. This cytotoxic compound was 20-fold more potent than acronycine in …
mechanism of action. This cytotoxic compound was 20-fold more potent than acronycine in …
Sodium cantharidinate, a novel anti-pancreatic cancer agent that activates functional p53
X Liu, L Zhang, PM Thu, W Min, P Yang, J Li… - Science China Life …, 2021 - Springer
Despite the use of many types of chemotherapies for pancreatic cancer, optimal efficacy has
not been obtained so far. Pancreatic cancer shows a high incidence of TP53 mutations …
not been obtained so far. Pancreatic cancer shows a high incidence of TP53 mutations …
Extracellular signal-regulated kinase activation and Bcl-2 downregulation mediate apoptosis after gemcitabine treatment partly via a p53-independent pathway
GC Chang, SL Hsu, JR Tsai, WJ Wu, CY Chen… - European journal of …, 2004 - Elsevier
Gemcitabine is a promising compound for the treatment of human lung cancer. Although
apoptosis has been shown to play a role in certain cell types with gemcitabine, the steps …
apoptosis has been shown to play a role in certain cell types with gemcitabine, the steps …
The molecular basis of radiosensitivity and chemosensitivity in the treatment of breast cancer
F Xia, SN Powell - Seminars in radiation oncology, 2002 - Elsevier
The molecular basis of sensitivity to therapeutic rediation and chemotherapy is a complex
product of cellular and tissue responses. Certain genetic factors can be highlighted as being …
product of cellular and tissue responses. Certain genetic factors can be highlighted as being …
The secreted protein acidic and rich in cysteine (SPARC) induces endoplasmic reticulum stress leading to autophagy-mediated apoptosis in neuroblastoma
GS Sailaja, P Bhoopathi… - International …, 2013 - spandidos-publications.com
Our previous studies showed that overexpression of secreted protein acidic and rich in
cysteine (SPARC) induced autophagy-mediated apoptosis in PNET cells. In the present …
cysteine (SPARC) induced autophagy-mediated apoptosis in PNET cells. In the present …
The SV2 variant of KLF6 is down-regulated in hepatocellular carcinoma and displays anti-proliferative and pro-apoptotic functions
BACKGROUND & AIMS: KLF6 protein is a transcription factor that plays important functions
in hepatocellular carcinoma (HCC), which is one of the leading causes of death by cancer …
in hepatocellular carcinoma (HCC), which is one of the leading causes of death by cancer …
[HTML][HTML] Antioxidant activity and leukemia initiation prevention in vitro and in vivo by N‑acetyl‑L‑cysteine
WL Shih, CD Chang, HT Chen… - Oncology …, 2018 - spandidos-publications.com
Abstract N‑acetyl‑L‑cysteine (NAC) is the most abundant water‑soluble component of garlic.
No study to date has studied the leukemia prevention ability of NAC in mouse systemic …
No study to date has studied the leukemia prevention ability of NAC in mouse systemic …