The role of p53 in gemcitabine-mediated cytotoxicity and radiosensitization

高春玲，陈玉强，戴云洁，宋维芳，谢立青 - 中华放射肿瘤学杂志, 2010 - cqvip.com

目的探讨吉西他滨(GEM) 是否对非小细胞肺癌具有放射增敏作用, 并对GEM
的放射增敏机制进行初步探讨. 方法用克隆形成分析法观察GEM 对p53 基因突变的人肺腺癌 …

UMP/CMPK is not the critical enzyme in the metabolism of pyrimidine ribonucleotide and activation of deoxycytidine analogs in human RKO cells

R Hu, W Lam, CH Hsu, YC Cheng - PLoS One, 2011 - journals.plos.org

Background Human UMP/CMP kinase was identified based on its enzymatic activity in vitro.
The role of this protein is considered critical for the maintenance of pyrimidine nucleotide …

被引用次数：11 相关文章所有 13 个版本

[PDF] academia.edu

[PDF][PDF] Kombination von Radiotherapie und Gemcitabine

S Mose, R Class, HW Weber, Á Oszvald… - Strahlentherapie und …, 2002 - academia.edu

Hintergrund: Das Nukleosidanalogon Gemcitabine weist im Experiment
radiotherapieverstärkende Eigenschaften auf. Die vorliegende Übersichtsarbeit versucht …

被引用次数：16 相关文章所有 5 个版本

[PDF] researchgate.net

Gemcitabine: Mechanism of Action and Resistance

AM Bergman, GJ Peters - Deoxynucleoside Analogs in Cancer Therapy, 2006 - Springer

Abstract Gemcitabine (2′, 2′-difluorodeoxycytidine, Gemzar®) is a deoxycytidine analog
with pronounced antitumor activity against a variety of solid tumors, such as non-small cell …

被引用次数：11 相关文章所有 5 个版本

Noxa Enhances the Cytotoxic Effect of Gemcitabine in Human Ovarian Cancer Cells

K Cao, J Yang, C Lin, B Wang, Y Yang… - Cancer Biotherapy …, 2012 - liebertpub.com

Noxa is an important proapoptotic protein in the intrinsic pathway of cell apoptosis.
Experiments were carried out to investigate whether Noxa could, therefore, enhance the …

被引用次数：8 相关文章所有 4 个版本

[PDF] ethernet.edu.et

Nucleoside radiosensitizers

DS Shewach, TS Lawrence - Deoxynucleoside analogs in cancer therapy, 2006 - Springer

Nucleoside/nucleobase analogs (bromodeoxyuridine, iododeoxyuridine, 5fluorouracil,
fluorodeoxyuridine, difluorodeoxycytidine, fluoroadenine arabinoside …

被引用次数：10 相关文章所有 5 个版本

[PDF] hal.science

Mécanisme d'action de nouveaux agents alkylants ciblant l'ADN ou les protéines

G Lenglet - 2010 - theses.hal.science

Le S23906-1 est un dérivé diacétate de la benzo-[b]-acronycine. Sélectionné pour son
potentiel cytotoxique in vitro et son activité anti-tumorale in vivo, ce composé très prometteur …

被引用次数：6 相关文章所有 5 个版本

VP3 基因联合吉西他滨诱导人膀胱癌细胞凋亡的实验研究

袁顺辉，王剑松，李泽惠，詹辉，李天庆 - 现代泌尿外科杂志, 2009 - cqvip.com

目的探讨鸡贫血病毒VP3 基因在人膀胱癌EJ 细胞株中的表达, 观察VP3 基因联合吉西他滨诱导
人膀胱癌EJ 细胞株凋亡的效应. 方法用真核表达载体PcDNA3-VP3 转染人膀胱癌EJ 细胞株 …

被引用次数：1 相关文章所有 3 个版本

S-phase cell-specific modification by gemcitabine of PFGE-analyzed radiation-induced DNA fragmentation and rejoining

A Jensen, J Debus, KJ Weber - International journal of radiation …, 2008 - Taylor & Francis

Purpose: To assess the cell cycle-dependent influence of gemcitabine on ionizing radiation-
induced DNA double-strand breakage (DSB) and rejoining measured by pulsed-field gel …

被引用次数：6 相关文章所有 4 个版本

辐射增敏药吉西他滨研究进展

高春玲，谢立青，王瑞芝 - 国外医学: 肿瘤学分册, 2005 - cqvip.com