Inflammasomes are critical sentinels of the innate immune system that respond to threats to
the host through recognition of distinct molecules, known as pathogen-or damage …

Pyroptosis is a lytic and inflammatory type of programmed cell death that is usually triggered
by inflammasomes and executed by gasdermin proteins. The main characteristics of …

Abstract Inflammatory caspases (caspases 1, 4, 5 and 11) are activated in response to
microbial infection and danger signals. When activated, they cleave mouse and human …

INTRODUCTION Canonical inflammasomes are multicomponent protein complexes that
play key roles in immune surveillance of infections and danger by activating caspase-1 …

Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host
response to infection. Recently was been found that pyroptosis is a unique form of …

Trillium tschonoskii Maxim (TTM), a traditional Chinese medicine, has been demonstrated to
have a potent anti-tumor effect. Recently, polyphyllin VI (PPVI), a main saponin isolated from …

Inflammatory caspases play a central role in innate immunity by responding to cytosolic
signals and initiating a twofold response. First, caspase‐1 induces the activation and …

Inflammasome biology is one of the most exciting and rapidly growing areas in immunology.
Over the past 10 years, inflammasomes have been recognized for their roles in the host …

Recent studies have offered a glimpse into the sophisticated mechanisms by which
inflammasomes respond to danger and promote secretion of interleukin (IL)-1β and IL-18 …

Neuroinflammation has been identified as a causative factor of multiple neurological
diseases. The nucleotide-binding oligomerization domain-, leucine-rich repeat-and pyrin …