Misfolding and aggregation of alpha‐synuclein (α‐synuclein) with concomitant cytotoxicity is
a hallmark of Lewy body related disorders such as Parkinson's disease, dementia with Lewy …

Cellular models are instrumental in dissecting a complex pathological process into simpler
molecular events. Parkinson's disease is multifactorial and clinically heterogeneous; the …

Studies of Parkinson's disease (PD) have been hindered by lack of access to affected
human dopaminergic (DA) neurons. Here, we report generation of induced pluripotent stem …

Parkinson's disease (PD) is a debilitating neurodegenerative condition characterized by the
loss of dopaminergic neurons in substantia nigra. MPP+ as a dopaminergic neurotoxin …

Aim: Lund human mesencephalic (LUHMES) cells can be differentiated to post-mitotic cells
with biochemical, morphological and functional features of dopaminergic (DAergic) neurons …

Neurodegenerative diseases are highly debilitating conditions characterised primarily by
progressive neuronal loss and impairment of the nervous system. Parkinson's disease (PD) …

Parkinson's disease (PD) is a progressive neurodegenerative disease with motor and non-
motor symptoms. PD is characterized by the degeneration of dopaminergic neurons in the …

Our understanding of the underlying molecular mechanism of Parkinson's disease (PD) is
hampered by a lack of access to affected human dopaminergic (DA) neurons on which to …

Histone deacetylases (HDACs) are key epigenetic enzymes and emerging drug targets in
cancer and neurodegeneration. Pan-HDAC inhibitors provided neuroprotection in …

Research on Parkinson's disease (PD) and drug development is hampered by the lack of
suitable human in vitro models that simply and accurately recreate the disease conditions …