Gene regulatory networks and tissue morphogenetic events drive the emergence of shape
and function: the pillars of embryo development. Although model systems offer a window …

BACKGROUND Trophectoderm (TE) biopsy and next generation sequencing (NGS) are
currently the preferred techniques for preimplantation genetic testing for aneuploidies (PGT …

Most human pre-implantation embryos are mosaics of euploid and aneuploid cells. To
determine the fate of aneuploid cells and the developmental potential of mosaic embryos …

Aneuploidy, chromosome stoichiometry that deviates from exact multiples of the haploid
compliment of an organism, exists in eukaryotic microbes, several normal human tissues …

Whole-chromosome imbalances affect over half of early human embryos and are the
leading cause of pregnancy loss. While these errors frequently arise in oocyte meiosis …

Background: Preimplantation genetic testing (PGT) is widely used today in in-vitro
fertilization (IVF) centers over the world for selecting euploid embryos for transfer and to …

Subfertility is common and affects one in six couples, half of whom lack an explanation for
their delay in conceiving. Developments in the diagnosis and treatment of subfertility over …

Compared to most mammals, human pregnancy is unusual in that it involves chromosomally
diverse embryos, cyclical breakdown and regeneration of the uterine mucosa, and intimate …

BACKGROUND Embryos that are able to form blastocysts have succeeded in activating their
genome and differentiating into two cell types—an external layer of trophectoderm cells …

Embryonic mosaicism, defined as the presence of karyotypically distinct cell lines within an
embryo, has been frequently reported with a high incidence in preimplantation embryos …