Reactive oxygen or nitrogen species (ROS/RNS) generated endogenously or in response to
environmental stress have long been implicated in tissue injury in the context of a variety of …

More than half of cancer patients receive radiotherapy as a part of their cancer treatment.
DNA double-strand breaks (DSBs) are considered as the most lethal form of DNA damage …

Abstract The phosphatidylinositol 3-kinase (PI3K)/Akt pathway is a key cascade downstream
of several protein kinases, especially membrane-bound receptor tyrosine kinases, including …

The treatment of cancer with chemotherapeutic agents and radiation has two major
problems: time-dependent development of tumor resistance to therapy (chemoresistance …

Head and neck squamous cell carcinoma (HNSCC) is strongly associated with alcohol and
tobacco consumption. Lately, the incidence of human papillomavirus (HPV)‐related tumors …

Background & Aims: Interleukin 6 (IL-6)-mediated signal transducers and activators of
transcription 3 (STAT-3) phosphorylation (activation) is aberrantly sustained in …

The epidermal growth factor receptor variant III (EGFRvIII) is associated with increased
proliferation of glioma cells. However, the impact of EGFRvIII on survival of patients with …

The epidermal growth factor receptor (EGFR), which is frequently expressed in tumors of
epithelial origin, is an important determinant of tumor responses to ionizing radiation …

The serine/threonine kinase AKT, also known as protein kinase B (PKB), is the major
substrate to phosphoinositide 3-kinase (PI3K) and consists of three paralogs: AKT1 (PKBα) …

Despite recent advances in radiotherapy, a majority of patients diagnosed with pancreatic
cancer (PC) do not achieve objective responses due to the existence of intrinsic and …