[HTML][HTML] Clinical potential of an enzyme-based novel therapy for cocaine overdose
It is a grand challenge to develop a truly effective medication for treatment of cocaine
overdose. The current available, practical emergence treatment for cocaine overdose …
overdose. The current available, practical emergence treatment for cocaine overdose …
In vivo characterization of toxicity of norcocaethylene and norcocaine identified as the most toxic cocaine metabolites in male mice
Background Majority of cocaine users also consume alcohol, and concurrent use of cocaine
and alcohol produces cocaethylene, norcocaine, norcocaethylene, and other non-toxic …
and alcohol produces cocaethylene, norcocaine, norcocaethylene, and other non-toxic …
Clinical potential of a rationally engineered enzyme for treatment of cocaine dependence: Long-lasting blocking of the psychostimulant, discriminative stimulus, and …
It is a grand challenge to develop a truly effective treatment of substance use disorder
(SUD), particularly for cocaine and other drugs without an FDA-approved treatment …
(SUD), particularly for cocaine and other drugs without an FDA-approved treatment …
Simultaneous determination of cocaine, ecgonine methyl ester, benzoylecgonine, cocaethylene and norcocaine in dried blood spots by ultra-performance liquid …
LLF Lizot, ACC da Silva, MF Bastiani, RZ Hahn… - Forensic science …, 2019 - Elsevier
Cocaine (COC) is one of the most widely abused drugs in the world and its sensitive and its
reliable measurement in blood is of great importance in the field of forensic and clinical …
reliable measurement in blood is of great importance in the field of forensic and clinical …
[HTML][HTML] Long-lasting blocking of interoceptive effects of cocaine by a highly efficient cocaine hydrolase in rats
Cocaine dependence is a serious world-wide public health problem without an FDA-
approved pharmacotherapy. We recently designed and discovered a highly efficient long …
approved pharmacotherapy. We recently designed and discovered a highly efficient long …
Kinetic characterization of an efficient cocaine hydrolase against toxic metabolites of cocaine
In the presence of alcohol, cocaine metabolism produces a number of metabolites, including
three toxic ones (cocaethylene, norcocaine, and norcocaethylene) which are all more toxic …
three toxic ones (cocaethylene, norcocaine, and norcocaethylene) which are all more toxic …
Rapid profiling and pharmacokinetic studies of multiple potential bioactive triterpenoids in rat plasma using UPLC/Q-TOF-MS/MS after oral administration of Ilicis …
B Yang, H Li, Q Ruan, Y Tong, Z Liu, S Xuan, J Jin… - Fitoterapia, 2018 - Elsevier
Triterpenoids, the major bioactive ingredients of Ilicis Rotundae Cortex, contributes a
significant cardiovascular protection activity. Although many studies about the total saponins …
significant cardiovascular protection activity. Although many studies about the total saponins …
Catalytic reaction mechanism for drug metabolism in human carboxylesterase-1: cocaine hydrolysis pathway
Carboxylesterase-1 (CE-1) is a crucial enzyme responsible for metabolism/activation/
inactivation of xenobiotics (therapeutic agents, prodrugs, abused drugs, and …
inactivation of xenobiotics (therapeutic agents, prodrugs, abused drugs, and …
Effectiveness of a cocaine hydrolase for cocaine toxicity treatment in male and female rats
Abstract Development of a truly effective medication for treatment of cocaine abuse has
been a grand challenge. There is no FDA-approved therapeutic agent specific for cocaine …
been a grand challenge. There is no FDA-approved therapeutic agent specific for cocaine …
Isolation and characterization of reference standard candidates for cocaine and benzoylecgonine obtained from illicit substances seized
CJ Macrino, NA Dos Santos… - Journal of Forensic …, 2024 - Wiley Online Library
The area of forensic chemistry has been growing and developing as a line of research due
to the high demands of public safety that require increasingly reliable results due to their …
to the high demands of public safety that require increasingly reliable results due to their …