Evaluation of hemaPEN® sampling device for measurement of cocaine and metabolites in capillary blood by LC-MS/MS

M Smidt, MF Bastiani, RZ Hahn, L Lima Feltraco Lizot… - Bioanalysis, 2022 - Taylor & Francis
Background: Dried blood spot sampling has been reported for on-site collection of
specimens, but measurements are affected by blood hematocrit, and special handling is …

Analysis of conventional and nonconventional forensic specimens in drug-facilitated sexual assault by liquid chromatography and tandem mass spectrometry

N Almofti, A Ballesteros-Gómez, S Rubio… - Talanta, 2022 - Elsevier
The incidence of drug-facilitated sexual assault (DFSA) has dramatically increased in the
last decades. Forensic analytical scientists continuously seek new methods and specimens …

Reengineering of albumin-fused cocaine hydrolase CocH1 (TV-1380) to prolong its biological half-life

Y Cai, S Zhou, Z Jin, H Wei, L Shang, J Deng… - The AAPS journal, 2020 - Springer
Therapeutic treatment of cocaine toxicity or addiction is a grand medical challenge. As a
promising therapeutic strategy for treatment of cocaine toxicity and addiction to develop a …

Catalytic activities of cocaine hydrolases against the most toxic cocaine metabolite norcocaethylene

X Zheng, X Chen, T Zhang, M Zhan, CG Zhan… - Organic & …, 2020 - pubs.rsc.org
A majority of cocaine users also consume alcohol. The concurrent use of cocaine and
alcohol produces the pharmacologically active metabolites cocaethylene and …

[HTML][HTML] Effects of alcohol on metabolism and toxicity of cocaine in rats

L Shang, X Zheng, T Zhang, J Deng, CG Zhan… - Toxicology Reports, 2022 - Elsevier
As most cocaine users drink alcohol, it is interesting to understand how a non-lethal dose of
alcohol affects the metabolism and toxicity of cocaine. In this study, we examined the …

SPE-UHPLC-ESI-MS/MS Analysis of Cocaine and Its Metabolites in Conventional and Alternative Biological Specimens: Application to Real Samples

HS Makhdoom, S Afzal, K Sultana, SNH Shah… - ACS …, 2024 - ACS Publications
An increase in cocaine abuse has been observed globally since the past decade. Cocaine
is among the commonly abused stimulants used for recreational purposes. In this study, the …

Cocaine, crack cocaine, and ethanol: A deadly mix

ET Shimomura, GF Jackson, BD Paul - Critical Issues in Alcohol and Drugs …, 2019 - Elsevier
Abusing cocaine and alcohol at the same time is a deadly combination due to the formation
of a unique metabolite of cocaine, cocaethylene (CE). In contrast to benzoylecgonine (BZ) …

Cocaine in different matrices: recent updates on pretreatment and detection techniques

Y Song, Y Zhang, L Wang, C Hu, ZF Liu… - Critical Reviews in …, 2024 - Taylor & Francis
Cocaine abuse has attracted increased attention in the recent past since it can cause
addiction and great harm to the normal human body. Due to cocaine exists in various …

Effects of cebranopadol on cocaine-induced hyperactivity and cocaine pharmacokinetics in rats

H Wei, L Shang, CG Zhan, F Zheng - Scientific Reports, 2020 - nature.com
Cebranopadol is known as a highly potent analgesic. Recent studies also demonstrated that
administration of cebranopadol significantly decreased cocaine self-administration and …

Transesterification of Indazole-3-carboxamide synthetic cannabinoids: identification of metabolite biomarkers for diagnosing co-abuse of 5F-MDMB-PINACA and …

Z Wang, CY Fong, EML Goh, HY Moy… - Journal of Analytical …, 2022 - academic.oup.com
Concurrent use of alcohol with synthetic cannabinoids (SCs) has been widely recorded
among drug abusers. The susceptibilities of three indazole-3-carboxamide type SCs with …